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Verbesserung der intestinalen Resorption von Peptidwirkstoffen mit Hilfe von Gallensäuren, insbesondere Cholylsarcosin

Michael, Susanne

English Title: Improvement of the intestinal resorption of peptide drugs with bile acids especially Cholylsarcosine

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Abstract

Thema dieser Dissertation war die Untersuchung des Einflusses von Cholylsarcosin-Na auf die Aufnahme von Peptiden aus dem Darm. Vergleichend dazu sollten natürliche Gallensalze als Resorptionsenhancer getestet werden. Die resorptionsverbessernden Eigenschaften von Cholylsarcosin-Na (CS-Na) wurden im Verhältnis zu CDCA-Na, TC-Na und UDCA-Na beurteilt. Es konnte gezeigt werden, daß eine 1 ige Lösung von CS-Na den Transport der Modellpeptide, Desmopressin und Octreotid, durch CaCo-2 Monolayer verbessert.

Translation of abstract (English)

The subject of this thesis was to study the influence of cholylsarcosin-Na (CS-Na) on the uptake of peptides out of the intestinal lumen. In comparison to this natural bile salts were tested as resorption enhancers. The results showed that CS-Na is a promising resorption enhancer for the modell peptides testet e.g. desmopressine and octreotide.

Item Type: Dissertation
Supervisor: Fricker, Prof. Dr. Gert,
Date of thesis defense: 15. December 2000
Date Deposited: 05. Jan 2001 00:00
Date: 2000
Faculties / Institutes: The Faculty of Bio Sciences > Institute of Pharmacy and Molecular Biotechnology
Subjects: 540 Chemistry and allied sciences
Controlled Keywords: Resorption, Gallensalze, Peptide
Uncontrolled Keywords: Resorptionsverbesserung, Cholylsarcosincholylsarcosine, resorption enhancement
Additional Information: Teile in: European Journal of Pharmaceutical Sciences
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