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Overall survival after reirradiation of spinal metastases – independent validation of predictive models

Bürgy, Daniel ; Siedlitzki, Lena ; Boda-Heggemann, Judit ; Wenz, Frederik ; Lohr, Frank

In: Radiation Oncology, 11 (2016), Nr. 35. pp. 1-7. ISSN 1748-717X

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Abstract

Background: It is unknown if survival prediction tools (SPTs) sufficiently predict survival in patients who undergo palliative reirradiation of spinal metastases. We therefore set out to clarify if SPTs can predict survival in this patient population. Methods: We retrospectively analyzed spinal reirradiations performed (n = 58, 52 patients, 44 included in analysis). SPTs for patients with spinal metastases were identified and compared to a general palliative score and to a dedicated SPT to estimate prognosis in palliative reirradiation independent of site (SPT-Nieder). Results: Consistently in all tests, SPT-Nieder showed best predictive performance as compared to other tools. Items associated with survival were general condition (KPS), liver metastases, and steroid use. Other factors like primary tumor site, pleural effusion, and bone metastases were not correlated with survival. We adapted an own score to the data which performed comparable to SPT-Nieder but avoids the pleural effusion item. Both scores showed good performance in identifying long-term survivors with late recurrences. Conclusions: Survival prediction in case of spinal reirradiation is possible with sufficient predictive separation. Applying SPTs in case of reirradiation helps to identify patients with good life expectancy who might benefit from dose escalation or longer treatment courses.

Document type: Article
Journal or Publication Title: Radiation Oncology
Volume: 11
Number: 35
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 09 Mar 2016 08:24
Date: 2016
ISSN: 1748-717X
Page Range: pp. 1-7
Faculties / Institutes: Medizinische Fakultät Mannheim > Klinik für Strahlentherapie und Radioonkologie
DDC-classification: 610 Medical sciences Medicine
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