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GAW20: methods and strategies for the new frontiers of epigenetics and pharmacogenomics

Tintle, Nathan L. ; Fardo, David W. ; de Andrade, Mariza ; Aslibekyan, Stella ; Bailey, Julia N. ; Bermejo, Justo Lorenzo ; Cantor, Rita M. ; Ghosh, Saurabh ; Melton, Philip ; Wang, Xuexia ; MacCluer, Jean W. ; Almasy, Laura

In: BMC Proceedings, 12 (2018), Nr. 9:26. pp. 1-3. ISSN 1753-6561

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Download (171kB) | Lizenz: Creative Commons LizenzvertragGAW20: methods and strategies for the new frontiers of epigenetics and pharmacogenomics by Tintle, Nathan L. ; Fardo, David W. ; de Andrade, Mariza ; Aslibekyan, Stella ; Bailey, Julia N. ; Bermejo, Justo Lorenzo ; Cantor, Rita M. ; Ghosh, Saurabh ; Melton, Philip ; Wang, Xuexia ; MacCluer, Jean W. ; Almasy, Laura underlies the terms of Creative Commons Attribution 3.0 Germany

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Abstract

GAW20 provided a platform for developing and evaluating statistical methods to analyze human lipid-related phenotypes, DNA methylation, and single-nucleotide markers in a study involving a pharmaceutical intervention. In this article, we present an overview of the data sets and the contributions analyzing these data. The data, donated by the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) investigators, included data from 188 families (N = 1105) which included genome-wide DNA methylation data before and after a 3-week treatment with fenofibrate, single-nucleotide polymorphisms, metabolic syndrome components before and after treatment, and a variety of covariates. The contributions from individual research groups were extensively discussed prior, during, and after the Workshop in groups based on discussion themes, before being submitted for publication.

Document type: Article
Journal or Publication Title: BMC Proceedings
Volume: 12
Number: 9:26
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 23 Oct 2018 10:51
Date: 2018
ISSN: 1753-6561
Page Range: pp. 1-3
Faculties / Institutes: Medizinische Fakultät Heidelberg > Institut für Medizinische Biometrie und Informatik
DDC-classification: 610 Medical sciences Medicine
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