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Effects of MitraClip on cognitive and psychological function in heart failure patients: the sicker the better

Terhoeven, Valentin ; Nikendei, Christoph ; Cranz, Anna ; Weisbrod, Matthias ; Geis, Nicolas ; Raake, Philip W. ; Katus, Hugo A. ; Herzog, Wolfgang ; Friederich, Hans-Christoph ; Schultz, Jobst-Hendrik ; Pleger, Sven T.

In: European Journal of Medical Research, 24 (2019), Nr. 14. pp. 1-8. ISSN 2047-783X

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Download (908kB) | Lizenz: Creative Commons LizenzvertragEffects of MitraClip on cognitive and psychological function in heart failure patients: the sicker the better by Terhoeven, Valentin ; Nikendei, Christoph ; Cranz, Anna ; Weisbrod, Matthias ; Geis, Nicolas ; Raake, Philip W. ; Katus, Hugo A. ; Herzog, Wolfgang ; Friederich, Hans-Christoph ; Schultz, Jobst-Hendrik ; Pleger, Sven T. underlies the terms of Creative Commons Attribution 4.0

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Abstract

Purpose: Cognitive impairment and reduced quality of life is a common condition in patients with heart failure (HF). Percutaneous mitral valve repair using (PMVR) MitraClip (MC) has emerged as a promising interventional tool, reducing all-cause mortality and hospitalization as well as increasing cognitive functioning and quality of life. However, the benefit of HF patients with severely depressed cognitive functioning remains unknown.

Methods: We assessed cognitive functioning (figural memory—FGT, executive function—TOL, TMT B), psychosocial functioning (depression—PHQ-9, quality of life—SF36), and clinical parameters (echocardiography, 6-min walk test distance, and cardiac biomarkers) 1 day before (t0) and 6 weeks after (t1) MC intervention in HF patients (n = 40). First, paired sample t tests were conducted to uncover improvements in cognitive functioning post-MC intervention. Second, the COGBAT Norm-sample, a representative age-matched healthy sample, was used to compare participants’ individual scores. Third, bivariate linear regressions were calculated for all key predictors of the detected improvements in cognitive functioning post-MC intervention (t1–t0).

Results: Following the MC intervention, we found significant improvements in figural memory, executive functioning, and psychosocial functioning. Most of the patients with depressed executive functioning before the MC intervention showed post-intervention test scores within the normal range (> 50th percentile; t0 22.5% vs. t1 60%) as compared to the normative COGBAT sample. Regression analyses revealed that lower baseline scores in planning ability before the MC intervention (t0) were associated with greater planning ability (TOL; B = − 0.78, 95% CI − 1.04 to − 0.53), figural memory (FGT; B = − 0.26, 95% CI − 0.44 to − 0.07), and cognitive flexibility (TMT B; B = − 0.36, 95% CI − 0.50 to − 0.23) improvement post-MC intervention (t1–t0). Psychosocial functioning and age were not associated with these improvements.

Conclusions: Patients with depressed executive functioning showed the greatest benefit from the MC intervention regarding cognitive functioning. Age and psychological functioning seem less important for cognitive performance improvements post-MC intervention. Hence, severely depressed cognitive functioning in patients is not a contraindication for PMVR using MitraClip.

Item Type: Article
Journal or Publication Title: European Journal of Medical Research
Volume: 24
Number: 14
Publisher: BioMed Central
Place of Publication: London
Date Deposited: 29 Apr 2019 07:53
Date: 2019
ISSN: 2047-783X
Page Range: pp. 1-8
Faculties / Institutes: Medizinische Fakultät Heidelberg > Medizinische Universitäts-Klinik und Poliklinik
Medizinische Fakultät Heidelberg > Psychiatrische Universitätsklinik
Medizinische Fakultät Heidelberg > Psychosomatische Universitätsklinik
Subjects: 150 Psychology
610 Medical sciences Medicine
Uncontrolled Keywords: Chronic heart failure, MitraClip intervention, Cognitive performance, Memory, Executive function, Depression, Quality of life
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