The EMBO Journal, 6 (6). pp. 1677-1683.
The gene for murine Ia-associated invariant (1i) chains (1131 and 1i41) was characterized by sequence analysis. The gene extends over - 9 kb and is organized in nine exons. Exon 1 encodes the 5' untranslated region and the cytoplasmic segment, exon 2 the membrane spaniing segment and adjacent amino acids and exons 3- 8 the extracytoplasmic portion of 1131. Putative promoter sequences were found upstream of the start of the coding sequence. Between exons 6 and 7 an additional, alternatively spliced exon 6b has been identified. This exon is spliced into the mRNA coding for the li-related Ii41 protein. Exon 6b encodes a cysteine-rich domain of 64 amino acids. It shows a remarkably high homology to the repetitive elements in thyroglobulin, a precursor for thyroid hormone. Based on this homology, it is suggested that this domain (TgR) in Tg and in 1141 may play a role either in hormone formation or as a carrier in the transport of molecules (thyroid hormone or processed antigen respectively) between intracellular compartments.
|Journal or Publication Title:||The EMBO Journal|
|Page Range:||pp. 1677-1683|
|Faculties / Institutes:||Service facilities > Center for Molecular Biology Heidelberg|
|Subjects:||570 Life sciences|
|Uncontrolled Keywords:||invariant chain gene, class II histocompatibility antigens , alternative-splicing , hyroglobulin , antigen processing|
|Schriftenreihe ID:||Works by Bernhard Dobberstein|