In: BMC Research Notes, 11 (2018), Nr. 879. pp. 1-7. ISSN 1756-0500

Preview

PDF, English - main document Download (1MB) | Lizenz: Anaemia requiring red blood cell transfusion is associated with unfavourable 90-day survival in surgical patients with sepsis by Kristof, Katalin ; Büttner, Benedikt ; Grimm, Anna ; Mewes, Caspar ; Schmack, Bastian ; Popov, Aron Frederik ; Ghadimi, Michael ; Beissbarth, Tim ; Hinz, José ; Bergmann, Ingo ; Mansur, Ashham underlies the terms of Creative Commons Attribution 4.0

Abstract

Objective: The mortality associated with sepsis remains unacceptably high, despite modern high-quality intensive care. Based on the results from previous studies, anaemia and its management in patients with sepsis appear to impact outcomes; however, the transfusion policy is still being debated, and the ideal approach may be extremely specific to the individual. This study aimed to investigate the long-term impact of anaemia requiring red blood cell (RBC) transfusion on mortality and disease severity in patients with sepsis. We studied a general surgical intensive care unit (ICU) population, excluding cardiac surgery patients. 435 patients were enrolled in this observational study between 2012 and 2016.

Results: Patients who received RBC transfusion between 28 days before and 28 days after the development of sepsis (n = 302) exhibited a significantly higher 90-day mortality rate (34.1% vs 19.6%; P = 0.004, Kaplan–Meier analysis). This association remained significant after adjusting for confounders in the multivariate Cox regression analysis (hazard ratio 1.68; 95% confidence interval 1.03–2.73; P = 0.035). Patients who received transfusions also showed significantly higher morbidity scores, such as SOFA scores, and ICU lengths of stay compared to patients without transfusions (n = 133). Our results indicate that anaemia and RBC transfusion are associated with unfavourable outcomes in patients with sepsis.