In: Pathobiology, 79 (2012), Nr. 1. pp. 11-17. ISSN 1015-2008
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Abstract
Objective: According to recent research, prolyl hydroxylase domain 2 protein (PHD2) plays an important role in human carcinogenesis by inducing neovascularization and tumor growth. The aim of this study was to evaluate PHD2 expression patterns in primary gastric adenocarcinoma and to test for a potential predictive value of PHD2 expression in gastric cancer patients. Methods: In a total of 121 patients, PHD2 expression was investigated by immunohistochemistry in paraffin- embedded tissue and correlated with clinicopathological parameters and patient survival. Results: 64 of 121 gastric carcinomas (52.9%) showed PHD2 expression in tumor cell cytoplasm. In univariate analysis, PHD2- negative patients had a significantly shortened survival in comparison
Document type: | Article |
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Journal or Publication Title: | Pathobiology |
Volume: | 79 |
Number: | 1 |
Publisher: | S. Karger AG |
Date Deposited: | 11 Dec 2014 08:03 |
Date: | 2012 |
ISSN: | 1015-2008 |
Page Range: | pp. 11-17 |
Faculties / Institutes: | Medizinische Fakultät Heidelberg > Pathologisches Institut |
DDC-classification: | 610 Medical sciences Medicine |