In: Kidney & blood pressure research, 36 (2012), Nr. 1. pp. 162-171. ISSN 1420-4096
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Abstract
Background: Higher blood pressure and albuminuria are found in offspring of mothers who smoke during pregnancy. Whether or not kidney development is affected by maternal smoking is unknown. Methods: Sprague-Dawley rats were randomly allocated to twice-daily cigarette-smoke and nicotine condensate (1 mg/kg) or vehicle at day 10 of pregnancy until delivery. Results: Exposed offspring did not differ from control offspring with respect to body weight, kidney weight, albuminuria, and creatinine clearance. Both male and female offspring had higher tail-plethysmographic blood pressures and lower mean glomerular volume, podocyte, mesangial-cell, and endothelial-cell number, compared to control offspring. Conclusions: The data document that prenatal exposure to cigarette-smoke condensate containing nicotine influences normal kidney development and could predispose to higher blood pressures later in life. Copyright (c) 2012 S. Karger AG, Basel
Document type: | Article |
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Journal or Publication Title: | Kidney & blood pressure research |
Volume: | 36 |
Number: | 1 |
Publisher: | S. Karger AG |
Date Deposited: | 11 Dec 2014 08:24 |
Date: | 2012 |
ISSN: | 1420-4096 |
Page Range: | pp. 162-171 |
Faculties / Institutes: | Medizinische Fakultät Heidelberg > Medizinische Universitäts-Klinik und Poliklinik Medizinische Fakultät Heidelberg > Pathologisches Institut |
DDC-classification: | 610 Medical sciences Medicine |