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PreS2-TML peptide or guanidinium modified Gd-DOTA exhibits efficient cellular uptake

Wolf, Markus ; Bauder-Wüst, Ulrike ; Pipkorn, Rüdiger

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The majority of magnetic resonance contrast agents are restricted to the extracellular domains. For the development of novel, intracellular magnetic resonance contrast agents, we have designed Gd-DOTA derivatives comprising PreS2-TML peptide or ethylguanidinium as carrier moiety. Initial in vitro cell uptake studies with Jurkat cells revealed efficient contrast agent uptake for imaging purposes, in the range of 0.04 fmol/cell (PreS2-TML peptide) to 0.2 fmol/cell (ethylguanidinium) following 2 h incubations at 100 µM.

Item Type: Article
Date Deposited: 23 Mar 2006 14:54
Date: 2006
Faculties / Institutes: Service facilities > German Cancer Research Center (DKFZ)
Subjects: 610 Medical sciences Medicine
Controlled Keywords: NMR-Bildgebung, Kontrastmittel
Uncontrolled Keywords: MRI , contrats agent, guanidinium , PreS2TML
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