TY  - GEN
Y1  - 2010///
TI  - Development of a non-contrast-enhanced method for spatially resolved lung ventilation and perfusion measurement using Magnetic Resonance Imaging
N2  - Assessment of the pulmonary function remains a challenge for the development of suitable MRI techniques due to the unique lung tissue structure and its short effective transverse relaxation time (T2* = 1 ms). In this work, a new method of non-contrast-enhanced lung ventilation and perfusion MRI is presented. A 2D bSSFP pulse sequence (TR/TE/TA = 1.9/0.8/116 ms, 3-7 images/s, FA = 75°, ST = 10 mm, matrix = 128 x 128, GRAPPA 3) was implemented on a 1.5 T MR-scanner. The method uses fast image acquisition and submillisecond echo sampling to enhance the signal intensity in the pulmonary tissue. The proposed technique does not rely on respiratory and ECG-triggering. Application of non-rigid image registration was mandatory to compensate for the breathing motion. The rapid acquisition of time-resolved MR-data allowed observing intensity changes in corresponding lung areas modulated with respiratory and cardiac frequencies. Two different spectral analysis methods, Fourier decomposition (FD)  and wavelet analysis (WA) were used to produce ventilation- and perfusion-weighted images by retrieving information associated with both physiological frequencies (FD/WA-MRI). The imaging technique was used in volunteers to test the technical and medical reproducibility. For validation purposes a group of cystic fibrosis patients was examined using FD-MRI and dynamic Contrast-Enhanced MRI. A good correlation between both methods (r = 0.82, P < 0.05) was determined. Animal experiments were conducted for validation of FD-MRI  against other imaging modalities (CT and SPECT/CT).
ID  - heidok10833
A1  - Bauman, Grzegorz Leszek
AV  - public
KW  - Perfusion 
KW  -  Ventilation 
KW  -  Lunge 
KW  -  MRT 
KW  -  kontrastmittelfreiperfusion 
KW  -  ventilation 
KW  -  lung 
KW  -  MRI 
KW  -  non-contrast-enhanced
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/10833/
ER  -