title: Screening the cell adhesion activity of muscle skeletal progenitor cells on defined nanopatterns
creator: Hung Low, Carlos Alberto
subject: ddc-570
subject: 570 Life sciences
description: In living systems, the extracellular matrix (ECM) is a complex structural network of proteins that confine and supports cells adherent to it. In the process of cell adhesion,the cells spread out on the supporting microenviroment generating intracellular tension (mediated by actomyosin contractility). Such mechanical force modulates the formation of focal adhesion structures (FA). The ”local” generation of mechanical force in FA causes ”global” changes in cell shape and motility, modulation of gene expression and changes in cell proliferation, differentiation and survival. Due to their importance, FA are attractive targets for drug discovery and functional genomics studies. However, less is known about how cells mechanically sense and transduce external chemical and physical signals via FA as surface mechanosensors. The process of cell adhesion is mediated mainly through attachment and clustering of transmembrane integrins of the cell to ECM macromolecules, such as fibronectin,vitronectin, collagen and laminin. ECM proteins have been shown to contain ligand peptides that can influence cell behavior. In this thesis, the interaction of cells with different ECM peptide ligands is examined in order to determine the importance of this relationship in cell adhesion and differentiation.
date: 2010
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/11321/1/Hung_Thesis.pdf
identifier: DOI:10.11588/heidok.00011321
identifier: urn:nbn:de:bsz:16-opus-113219
identifier:   Hung Low, Carlos Alberto  (2010) Screening the cell adhesion activity of muscle skeletal progenitor cells on defined nanopatterns.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/11321/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng