TY  - GEN
A1  - Tataroglu, Ozgur
TI  - Role of Glycogen Synthase Kinase (GSK) in temperature compensation of the Neurospora circadian clock
N2  - Circadian clocks are biological oscillators that allow organisms to accurately predict and adjust to the rhythmic changes in the environment which increases their fitness. These oscillators are found in every cell and have three fundamental properties: they are endogenous, entrainable and temperature compensated. The former two properties of the clock are well studied. However, it is currently unknown how clocks accurately keep the time independent of the ambient temperature, a phenomenon known as ?temperature compensation?. This is particularly important for poikilothermic organisms that cannot control their body temperature and yet still have accurate circadian clocks. We used Neurospora crassa as a eukaryotic circadian clock model organism and showed that Glycogen synthase kinase (GSK) binds and specifically phosphorylates White Collar 1 (WC-1), which is the critical and rate-limiting positive element of the Neurospora clock. We found that these phosphorylations decrease the WC-1 stability in a temperature dependent manner. Our data completes the picture in our current understanding of temperature compensation of circadian clocks and shows that temperature compensation in Neurospora crassa is achieved by opposing functions of two kinases (GSK and CK2) on the positive (WCC) and negative (FRQ) elements of the clock, respectively. Since both kinases are well conserved among eukaryotes, it is also possible that this mechanism of temperature compensation is conserved among other eukaryotic circadian clocks.
ID  - heidok11639
AV  - public
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/11639/
KW  - circadian 
KW  -  temperature 
KW  -  compensation 
KW  -  glycogen 
KW  -  kinasecircadian 
KW  -  temperatur 
KW  -  kompensation 
KW  -  glykogen 
KW  -  kinase
Y1  - 2011///
ER  -