<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "The role of the Cholinergic System on Plasticity in the Basolateral Nucleus of the Amygdala"^^ . "The amygdala and the cholinergic system play important roles in learning and memory. The amygdala receives substantial cholinergic innervation and in itself ex-presses differences in this innervation. p75NTR is one of the primary receptors of cho-linergic neurons and transgenic mice that are missing exon IV of the p75 neurotro-phin receptor locus, display a change in cholinergic innervation. The loss of p75NTR can induce changes in learning and memory so it was hypothesized p75EXIV animals would display an enhancement in cholinergic induced plasticity in the amygdala, due to increased cholinergic innervation in these mice, and a difference between the BL and La nuclei would be seen. As expected, ChAT immunohistochemistry showed a stark difference in cholinergic innervation between the BL and La nuclei of the amyg-dala. Field potential recordings, as well as PPF and LTP, did not show any differences between BL and La in wt animals therefore sharp microelectrode recording and a standard plateau firing paradigm were used to determine intrinsic differences in pro-jection neurons for the BL and La nuclei. Sharp recordings revealed a difference in plateau firing induction for BL neurons as well as a hyperpolarizing membrane deflec-tion. As in wt animals, there were no differences seen between the BL and La for field recordings in ko mice; although, paired pulse facilitation and LTP elucidated a reduction in transmitter release as well as disrupted postsynaptic maintenance in p75EXIV animals as compared to wt. Field potential recordings with cholinergic chal-lenge also indicated a difference in cholinergic signaling in p75EXIV animals. In contrast with the original hypothesis, p75EXIV animals did not display an enhancement of cho-linergic induced plasticity in the amygdala but rather impairment."^^ . "2010" . . . . . . . . "Brandon H."^^ . "Cline"^^ . "Brandon H. Cline"^^ . . . . . . "The role of the Cholinergic System on Plasticity in the Basolateral Nucleus of the Amygdala (PDF)"^^ . . . "Dissertation_Cline_2011.pdf"^^ . . . "The role of the Cholinergic System on Plasticity in the Basolateral Nucleus of the Amygdala (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "The role of the Cholinergic System on Plasticity in the Basolateral Nucleus of the Amygdala (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "The role of the Cholinergic System on Plasticity in the Basolateral Nucleus of the Amygdala (Other)"^^ . . . . . . "preview.jpg"^^ . . . "The role of the Cholinergic System on Plasticity in the Basolateral Nucleus of the Amygdala (Other)"^^ . . . . . . "medium.jpg"^^ . . . "The role of the Cholinergic System on Plasticity in the Basolateral Nucleus of the Amygdala (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #11869 \n\nThe role of the Cholinergic System on Plasticity in the Basolateral Nucleus of the Amygdala\n\n" . "text/html" . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . .