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primary topic: Chromatin regulation by the histone acetyltransferase MOF in Drosphila

Chromatin regulation by the histone acetyltransferase MOF in Drosphila
type: Article
abstract: Like in mammals, sex determination in Drosophila melanogaster involves an unequal distribution of sex chromosomes, with male flies carrying an X and a Y chromosome, as compared to two Xs in females. To prevent the deleterious effects of chromosomal aneuploidy, flies have evolved a dosage compensation system, which upregulates transcription from the single male X chromosome to match transcript levels produced from the two female Xs. This transcriptional activation is achieved by the dosage compensation complex (DCC), a ribonucleoprotein complex consisting of five male specific lethal proteins (MSL) and two non coding RNAs on the X (roX). The DCC is physically tethered to hundreds of target loci along the male X chromosome, where it promotes hyper acetylation of X-linked chromatin at Lysine 16 of histone H4 (H4K16ac). This histone mark is associated with an open, permissive chromatin structure, and its enrichment on the male X chromosome is thought to be required for the twofold increase in X-linked transcription during dosage compensation. However, the exact mechanism by which X-linked transcription is activated in males is still unknown. Responsible for hyper-acetylation of the male X chromosome is the histone acetyltransferase males absent on the first (MOF), which is part of the DCC. Recent studies have shown that MOF plays an additional role in autosomal gene regulation, as it has been found at thousands of autosomal gene promoters as part of the non specific lethal (NSL) complex. However, to what extent H4K16ac at autosomal genes is MOF-dependent, and how MOF is differentially distributed between the two complexes is currently unknown. During the course of my PhD, I used genetic, biochemical, and genomewide approaches to address a wide range of questions, concerning MOF functions in autosomal gene regulation and dosage compensation; the DCC recruitment process to X-linked target genes; and the mechanism of transcriptional upregulation of X-linked genes during do…
date: 2011
status: published
author list: authors
type: EPrint
type: DoctoralThesisEPrint
is part of: repository
has document: Chromatin regulation by the histone acetyltransferase MOF in Drosphila (PDF)
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subject: 570 Biowissenschaften, Biologie

Chromatin regulation by the histone acetyltransferase MOF in Drosphila (PDF)
type: Document
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Thomas Conrad
type: Person
given name: Thomas
family name: Conrad

Chromatin regulation by the histone acetyltransferase MOF in Drosphila (Other)
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Chromatin regulation by the histone acetyltransferase MOF in Drosphila (Other)
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Chromatin regulation by the histone acetyltransferase MOF in Drosphila (Other)
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Chromatin regulation by the histone acetyltransferase MOF in Drosphila (Other)
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primary topic: Chromatin regulation by the histone acetyltransferase MOF in Drosphila

570 Biowissenschaften, Biologie
type: Concept
preferred label: 570 Life sciences @en