TY  - GEN
KW  - Kohlenstoffionentherpie 
KW  -  biologische OptimierungCarbon ion therapy 
KW  -  proton therapy 
KW  -  radiobiology 
KW  -  radiobiological optimization
ID  - heidok12243
Y1  - 2011///
A1  - Frese, Malte Christian
TI  - Potentials and Risks of Advanced Radiobiological Treatment Planning for Proton and Carbon Ion Therapy
N2  - After fifty years of particle therapy the technical capabilities are far advanced. Nevertheless, radiation biology is still poorly understood. Dose prescription and biological effect calculation are subject to large errors. It is the aim of this work to give a better understanding of the benefits but also the limitations and risks of particle therapy. In the first part of this thesis we studied and extended an existing biological treatment planning method for protons and carbon ions. We compared the simultaneous and sequential application of carbon ion boosts, the influence of constant and variable  relative biological effectiveness models in proton therapy, and the robustness of worst case and conventionally optimized treatment plans. The second part of this thesis focuses on improving radiobiological models. We developed an analytical model to calculate the linear energy transfer of carbon ion fragments, presented a method to incorporate oxygen effects into treatment planning, and extended the mechanistic repair-misrepair-fixation model to predict the biological effect of real proton and carbon ion treatment plans. In conclusion, we believe that significant advances in radiation biology will require more long term experience from systematic studies where human influence on plan quality is  minimized. Prompt improvements could be achieved by drastically extending the use of advanced optimization algorithms. 
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/12243/
AV  - public
ER  -