title: Quality control for peptide chip array production
creator: Wagner, Jennifer
subject: 530
subject: 530 Physics
description: This work establishes quality control for selective deposition of tribo-electrically charged micro-particles containing pre-activated amino acids onto a CMOS-chip in order to achieve high peptide densities in a modified Merrifield peptide synthesis. It encompasses the setup and implementation of an image processing supported auto- mated assessment of the particle depositions based on the analysis of the particles used, modelling the particle transfer out of an aerosol, deducing optimised param- eters and finding a surface analysis experiment that allows for semi-quantitative spatially resolved detection of amino acids coupled to the support in the microm- eter range. Furthermore, a flexible stand-alone interface to the control program of the automated system is implemented.
date: 2011
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/12602/1/report.pdf
identifier: DOI:10.11588/heidok.00012602
identifier: urn:nbn:de:bsz:16-opus-126029
identifier:   Wagner, Jennifer  (2011) Quality control for peptide chip array production.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/12602/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng