title: Interaction between Experiment, Modeling and Simulation of Spatial Aspects in the JAK2/STAT5 Signaling Pathway
creator: Friedmann, Elfriede
creator: Pfeifer, Andrea C.
creator: Neumann, Rebecca
creator: Klingmüller, Ursula
creator: Rannacher, Rolf
subject: ddc-510
subject: 510 Mathematics
description: Fundamental progress in systems biology can only be achieved if experimentalists and theoreticians closely collaborate. Mathematical models cannot be formulated precisely without deep knowledge of the experiments while complex biological systems can often not be understood fully without mathematical interpretation of the dynamic processes involved. In this article, we describe how these two approaches can be combined to gain new insights on one of the most extensively studied signal transduction pathways, the Janus kinase (JAK)/ signal transducer and activator of transcription (STAT) pathway. We focus on the parameters of a model describing how STAT proteins are transported from the membrane to the nucleus where STATs regulate gene expression. We discuss which parameters can be measured experimentally in different cell types and how the unknown parameters are estimated, what the limits of these techniques and how accurate the determinations are.
date: 2010
type: Preprint
type: info:eu-repo/semantics/preprint
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/12692/1/FriedmannPfeifer10.pdf
identifier: DOI:10.11588/heidok.00012692
identifier: urn:nbn:de:bsz:16-opus-126925
identifier:   Friedmann, Elfriede ; Pfeifer, Andrea C. ; Neumann, Rebecca ; Klingmüller, Ursula ; Rannacher, Rolf  (2010) Interaction between Experiment, Modeling and Simulation of Spatial Aspects in the JAK2/STAT5 Signaling Pathway.  [Preprint]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/12692/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng