TY  - GEN
N2  - Fundamental progress in systems biology can only be achieved if experimentalists and theoreticians closely collaborate. Mathematical models cannot be formulated precisely without deep knowledge of the experiments while complex biological systems can often not be understood fully without mathematical interpretation of the dynamic processes involved. In this article, we describe how these two approaches can be combined to gain new insights on one of the most extensively studied signal transduction pathways, the Janus kinase (JAK)/ signal transducer and activator of transcription (STAT) pathway. We focus on the parameters of a model describing how STAT proteins are transported from the membrane to the nucleus where STATs regulate gene expression. We discuss which parameters can be measured experimentally in different cell types and how the unknown parameters are estimated, what the limits of these techniques and how accurate the determinations are.
ID  - heidok12692
Y1  - 2010///
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/12692/
TI  - Interaction between Experiment, Modeling and Simulation of Spatial Aspects in the JAK2/STAT5 Signaling Pathway
KW  - JAK2/STAT5 Signalweg
KW  -  Reaktions-Diffusionsgleichungen
KW  -  ParameterschätzungJAK2/STAT5 Signaling Pathway
KW  -  Reaction Diffusion Equations
KW  -  Parameter Estimation
A1  - Friedmann, Elfriede
A1  - Pfeifer, Andrea C.
A1  - Neumann, Rebecca
A1  - Klingmüller, Ursula
A1  - Rannacher, Rolf
AV  - public
ER  -