%0 Generic
%A Cabal Arango, Gonzalo Alfonso
%D 2012
%F heidok:13678
%K Ionenstrahltherapie , TherapieplanungIon Beam Therapy , Treatment Planning , Plan Robustness , Beam Angle Selection , PTV definition
%R 10.11588/heidok.00013678
%T Novel methods for treatment planning in Ion Beam Therapy
%U https://archiv.ub.uni-heidelberg.de/volltextserver/13678/
%X One of the biggest challenges in ion beam therapy is the mitigation of the impact of uncertainties in the quality of treatment plans. Some of the strategies used to reduce this impact are based on concepts developed decades ago for photon therapy. In this thesis novel methods and concepts, tailored to the specifi c needs of ion beam therapy, are proposed which reduce the effect of uncertainties on treatment plans. This is done in two steps: First, we revisit the concept of the Planning Target Volume and propose a novel method for its de nition. This method enhances robustness of treatment plans and reduces the amount of healthy tissue irradiated. In a clinical situation this could translate into an enhancement of the tumor control probability while reducing side e ects. The concept of robust conformity (conformity in the presence of uncertainties) is proposed along with a way to quantify it. Secondly,a method to select robust beam angle con gurations that also spare organs at risks is proposed. This combination is a new conceptual layout to tackle the challenges of ion beam therapy and enhances its potential.