title: Dose Calculation Algorithms for Radiation Therapy with an MRI-Integrated Radiation Device
creator: Pfaffenberger, Asja
subject: ddc-530
subject: 530 Physics
subject: ddc-600
subject: 600 Technology (Applied sciences)
description: Image-guided adaptive radiation therapy (IGART) aims at improving therapy outcome on the basis of more precise knowledge of the anatomical and physiological situation during treatment. By integration of magnetic resonance imaging (MRI), better differentiation is possible between the target volume to be irradiated and healthy surrounding tissues. In addition, changes that occur either between or during treatment fractions can be taken into account. On the basis of this information, a better conformation of  radiation dose to the target volume may be achieved, which may in turn improve prognosis and reduce radiation side effects. This requires a precise calculation of radiation dose in a magnetic field that is present in these integrated irradiation devices. Real-time adaptation of the treatment plan is aimed at for which fast dose calculation is needed. Kernel-based methods are good candidates to achieve short calculation times; however, they presently only exist for radiation therapy in the absence of magnetic fields. This work suggests and investigates two approaches towards kernel-based dose calculation algorithms. One of them is integrated into treatment plan optimisation and applied to four clinical cases.
date: 2013
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/14551/1/Pfaffenberger_PhDThesis_Abgabeversion.pdf
identifier: DOI:10.11588/heidok.00014551
identifier: urn:nbn:de:bsz:16-heidok-145514
identifier:   Pfaffenberger, Asja  (2013) Dose Calculation Algorithms for Radiation Therapy with an MRI-Integrated Radiation Device.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/14551/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng