<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Mathematical Modeling of Hepatitis C Virus Replication"^^ . "At present, 170 million people are infected with Hepatitis C Virus, which is about\r\n3 % of the world population. Currently available treatment is successful in only 50\r\n% of treated patients. Further development of the treatment strategies requires a\r\nprofound quantitative understanding of the viral lifecycle. This remains a major\r\nchallenge, however, by combining the experimental and modeling approaches it has\r\nbecome possible to understand it quantitatively.\r\nIn this thesis, we develop a mathematical model to investigate the intracellular dynamics\r\nof HCV replication. In this model, two processes, the translation of viral\r\nproteins and the replication of viral genomes are considered. This model is established\r\nby using ordinary differential equations. The established model is then\r\ncalibrated by using the time course data representing the viral plus-, minus-strand\r\nRNA and the polyprotein dynamics and the steady state data reflecting the ratios\r\namong the plus-, minus-strand RNA and the non-structural proteins. Subsequently,\r\nthe model is validated using the independent measurements highlighting the replication\r\ndeficient and synthesis inhibited HCV RNA dynamics. Furthermore, the model\r\nis used to analyze the observed difference in HCV RNA replication in the clonal\r\nHuh-7 cell lines. We demonstrate that this difference can be explained by the differential\r\nexpression of the cellular host factor which involves in the replication of\r\nviral genomes. Using the model, a role of replication vesicles with respect to viral\r\ndynamics is analyzed. A sensitivity analysis is performed on the model parameters\r\nto reveal the crucial steps in the viral replication. This analysis shows that the processes\r\nin the replication vesicles are the most crucial for HCV replication. Finally,\r\nan identifiability analysis is performed to check whether the model parameters are sufficiently estimated from the measured data."^^ . "2013" . . . . . . . "Nurgazy"^^ . "Sulaimanov"^^ . "Nurgazy Sulaimanov"^^ . . . . . . "Mathematical Modeling of Hepatitis C Virus Replication (PDF)"^^ . . . "PhD Thesis.pdf"^^ . . . "Mathematical Modeling of Hepatitis C Virus Replication (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Mathematical Modeling of Hepatitis C Virus Replication (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Mathematical Modeling of Hepatitis C Virus Replication (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Mathematical Modeling of Hepatitis C Virus Replication (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Mathematical Modeling of Hepatitis C Virus Replication (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #14967 \n\nMathematical Modeling of Hepatitis C Virus Replication\n\n" . "text/html" . . . "500 Naturwissenschaften und Mathematik"@de . "500 Natural sciences and mathematics"@en . .