title: Tracking-by-Assignment as a Probabilistic Graphical  Model with Applications in Developmental Biology
creator: Kausler, Bernhard
subject: ddc-000
subject: 000 Generalities, Science
subject: ddc-004
subject: 004 Data processing Computer science
subject: ddc-500
subject: 500 Natural sciences and mathematics
subject: ddc-570
subject: 570 Life sciences
description: This thesis presents a novel approach for tracking a varying number of divisible  objects with similar appearance in the presence of a non-negligible number of false  positive detections (more than 10%). It is applied to the reconstruction of cell  lineages in developing zebrafish and fruit fly embryos from 3d time-lapse record-  ings. The model takes the form of a chain graph—a mixed directed-undirected  probabilistic graphical model—and a tracking is obtained simultaneously over all  time slices from the maximum a-posteriori configuration.  The tracking model is used as the second step in a two-step pipeline to produce  digital embryos—maps of cell nuclei in an embryo and their ancestral fate; the first  step being the segmentation of the fluorescently-stained cell nuclei in light sheet  microscopy images.  The pipeline is implemented as a software with an intuitive graphical user  interface. It is the first freely available program of its kind and makes the presented  methods accessible to a broad audience of users from the life sciences.
date: 2013
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/15296/1/bkausler_13_tracking.pdf
identifier: DOI:10.11588/heidok.00015296
identifier: urn:nbn:de:bsz:16-heidok-152962
identifier:   Kausler, Bernhard  (2013) Tracking-by-Assignment as a Probabilistic Graphical Model with Applications in Developmental Biology.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/15296/
rights: info:eu-repo/semantics/openAccess
rights: Please see front page of the work (Sorry, Dublin Core plugin does not recognise license id)
language: eng