title: Realizing a new paradigm in radiation therapy treatment planning
creator: Ziegenhein, Peter
subject: 004
subject: 004 Data processing Computer science
subject: 530
subject: 530 Physics
subject: 570
subject: 570 Life sciences
description: This thesis investigates the feasibility of a new IMRT planning paradigm called Interactive Dose Shaping (IDS).  The IDS paradigm enables the therapist to directly impose local dose features into the therapy plan. In contrast  to the conventional IMRT planning approach, IDS does not employ an objective function to drive an iterative  optimization procedure.  In the first part of this work, the conventional IMRT plan optimization method is investigated. Concepts for a  near-optimal implementation of the planning problem are provided. The second part of this work introduces the  IDS concept. It is designed to overcome clinical drawbacks of the conventional method on the one hand and to  provide interactive planning strategies which exploit the full potential of modern high-performance computer  hardware on the other hand. The realization of the IDS concept consists of three main parts. (1)A two-step Dose  Variation and Recovery (DVR) strategy which imposes localized plan features and recovers for unintentional  plan modifications elsewhere. (2)A new dose calculation method (3)The design of an IDS planning framework  which provides a powerful graphical user interface.  It could be shown that the IDS paradigm is able to reproduce conventionally optimized therapy plans and  that the IDS concepts can be realized in real-time.
date: 2013
type: Dissertation
type: info:eu-repo/semantics/doctoralThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/15403/1/diss_ziegenhein.pdf
identifier: DOI:10.11588/heidok.00015403
identifier: urn:nbn:de:bsz:16-heidok-154033
identifier:   Ziegenhein, Peter  (2013) Realizing a new paradigm in radiation therapy treatment planning.  [Dissertation]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/15403/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng