eprintid: 15403
rev_number: 13
eprint_status: archive
userid: 772
dir: disk0/00/01/54/03
datestamp: 2013-08-20 12:30:22
lastmod: 2013-08-23 08:41:55
status_changed: 2013-08-20 12:30:22
type: doctoralThesis
metadata_visibility: show
creators_name: Ziegenhein, Peter
title: Realizing a new paradigm in radiation therapy treatment planning
subjects: 004
subjects: 530
subjects: 570
divisions: 850300
adv_faculty: af-13
abstract: This thesis investigates the feasibility of a new IMRT planning paradigm called Interactive Dose Shaping (IDS).
The IDS paradigm enables the therapist to directly impose local dose features into the therapy plan. In contrast
to the conventional IMRT planning approach, IDS does not employ an objective function to drive an iterative
optimization procedure.
In the first part of this work, the conventional IMRT plan optimization method is investigated. Concepts for a
near-optimal implementation of the planning problem are provided. The second part of this work introduces the
IDS concept. It is designed to overcome clinical drawbacks of the conventional method on the one hand and to
provide interactive planning strategies which exploit the full potential of modern high-performance computer
hardware on the other hand. The realization of the IDS concept consists of three main parts. (1)A two-step Dose
Variation and Recovery (DVR) strategy which imposes localized plan features and recovers for unintentional
plan modifications elsewhere. (2)A new dose calculation method (3)The design of an IDS planning framework
which provides a powerful graphical user interface.
It could be shown that the IDS paradigm is able to reproduce conventionally optimized therapy plans and
that the IDS concepts can be realized in real-time.
date: 2013
id_scheme: DOI
id_number: 10.11588/heidok.00015403
ppn_swb: 766602656
own_urn: urn:nbn:de:bsz:16-heidok-154033
date_accepted: 2013-07-24
advisor: HASH(0x556120a829c0)
language: eng
bibsort: ZIEGENHEINREALIZINGA2013
full_text_status: public
citation:   Ziegenhein, Peter  (2013) Realizing a new paradigm in radiation therapy treatment planning.  [Dissertation]     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/15403/1/diss_ziegenhein.pdf