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primary topic: Poly(ethylene glycol) Micropillar Arrays as Force Sensors for Biophysical Applications

Poly(ethylene glycol) Micropillar Arrays as Force Sensors for Biophysical Applications
type: Article
abstract: Forces play a crucial role in the regulation and function of biological processes. One of the most commonly used tools for measuring forces are elastic micropillars made of poly(dimethylsiloxane). By using poly(ethylene glycol) (PEG) micropillars, several new ex- perimental approaches could be developed. The aim of this thesis was the enhancement and the experimental application of these PEG micropillars. Not only the achievable geometries, but also the functionalization potential was significantly enhanced. For this, the PEG micropillar fabrication was combined with the transfer of hexagonal gold nanoparticle structures to PEG hydrogels. As a result, PEG micropillars exhibiting gold nanoparticle structures on their tops were obtained. These gold nanoparticles can serve as anchor points for a variety of proteins or other biologically active compounds. To study integrin dependent cell adhesion they were func- tionalized with αvβ3- or α5β1-integrin selective peptidomimetics. Cell experiments showed that fibroblasts exerted higher maximum forces on the α5β1-integrin selective ligand than cells on the αvβ3-integrin ligand. These observations were supported by higher local zyxin densities in adhesion clusters and the analysis of further proteins involved in the adhesion process. Further- more, the achievable PEG pillar force resolution of 9 ± 2 pN was demonstrated by investigating the contractile forces of in vitro actin networks bundled by magnesium ions.
date: 2013
author list: authors
type: EPrint
type: DoctoralThesisEPrint
is part of: repository
has document: Poly(ethylene glycol) Micropillar Arrays as Force Sensors for Biophysical Applications (PDF)
has document: Poly(ethylene glycol) Micropillar Arrays as Force Sensors for Biophysical Applications (Other)
subject: 530 Physik
subject: 540 Chemie
subject: 570 Biowissenschaften, Biologie

Poly(ethylene glycol) Micropillar Arrays as Force Sensors for Biophysical Applications (PDF)
type: Document
has file: Dissertation_Sabri_Rahmouni.pdf
has part: Dissertation_Sabri_Rahmouni.pdf

Sabri Rahmouni
type: Person
given name: Sabri
family name: Rahmouni

Poly(ethylene glycol) Micropillar Arrays as Force Sensors for Biophysical Applications (Other)
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Poly(ethylene glycol) Micropillar Arrays as Force Sensors for Biophysical Applications (Other)
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primary topic: Poly(ethylene glycol) Micropillar Arrays as Force Sensors for Biophysical Applications

530 Physik
type: Concept
preferred label: 530 Physics @en

540 Chemie
type: Concept
preferred label: 540 Chemistry and allied sciences @en

570 Biowissenschaften, Biologie
type: Concept
preferred label: 570 Life sciences @en