<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Induction of a neuroprotective phenotype of macrophages\r\nby the β-hydroxybutyrate receptor HCA2"^^ . "Ketogenic diet is protective in models of ischemic stroke and neurodegenerative diseases. Currently, clinical trials are testing the efficacy of this diet in neurodegenerative diseases but its mode of action is still unclear. The ketone body β-hydroxybutyrate (BHB) is the endogenous agonist of the hydroxy-carboxylic acid receptor 2 (HCA2, GPR109A) which is expressed in various immune cells; therefore, we tested the potential involvement of this receptor in a mouse model of ischemic stroke.\r\nThe protective effect of ketogenic diet and BHB was lost in Hca2-/- mice, demonstrating that HCA2 receptors are responsible for neuroprotection. Similarly, nicotinic acid, a HCA2 agonist, reduced the infarct size via a HCA2-mediated mechanism. Immunohistochemical analysis of immune cells in Hca2mRFP transgenic mice revealed HCA2 expression in monocytes/macrophages. Bone marrow transplantation demonstrated that HCA2 on monocytes/macrophages is required for the protective effect. Activation of HCA2 receptors induced a neuroprotective phenotype of monocytes/macrophages that depended on PGD2 production by COX-1 and the hematopoietic PGD2 synthase. Our data reveal that HCA2 activation by dietary or pharmacological means instructs monocytes/macrophages to carry a neuroprotective signal to the brain which can be used therapeutically."^^ . "2013" . . . . "University of Heidelberg press"^^ . . . . . . "Md. Mahbubur"^^ . "Rahman"^^ . "Md. Mahbubur Rahman"^^ . . . . . . "Induction of a neuroprotective phenotype of macrophages\r\nby the β-hydroxybutyrate receptor HCA2 (PDF)"^^ . . . "PhD thesis_27.06.13 for submission.pdf"^^ . . . "Induction of a neuroprotective phenotype of macrophages\r\nby the β-hydroxybutyrate receptor HCA2 (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Induction of a neuroprotective phenotype of macrophages\r\nby the β-hydroxybutyrate receptor HCA2 (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Induction of a neuroprotective phenotype of macrophages\r\nby the β-hydroxybutyrate receptor HCA2 (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Induction of a neuroprotective phenotype of macrophages\r\nby the β-hydroxybutyrate receptor HCA2 (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Induction of a neuroprotective phenotype of macrophages\r\nby the β-hydroxybutyrate receptor HCA2 (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #15516 \n\nInduction of a neuroprotective phenotype of macrophages \nby the β-hydroxybutyrate receptor HCA2\n\n" . "text/html" . . . "500 Naturwissenschaften und Mathematik"@de . "500 Natural sciences and mathematics"@en . . . "570 Biowissenschaften, Biologie"@de . "570 Life sciences"@en . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .