<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Simulations, Optimizations, and Microdosimetric Measurements of Beam Quality for Heavy-Ion Tumor Therapy. A charged (particle) issue."^^ . "Tumor radiotherapy with charged particles offers superior properties in covering the tumor with radiation dose, while sparing the surrounding, healthy tissue better than standard X-rays. Thus, the success of the therapy is potentially increased. However, the application of this technique necessitates not only profound knowledge about its physical aspects, such as the uncertainties in the range of the particles which need to be taken into account in the therapy planning stage. In addition to the physical aspects, the biological effectiveness of particle radiation needs to be thoroughly understood. The effectiveness depends on many physical as well as biological quantities and is determined involving complicated models. Though, there is a close relation with the linear energy transfer (LET), i.e. the measure of the local concentration of energy deposition along a particle’s track. The higher the LET (up to a certain limit), the higher the biological effect. Furthermore, radiation resistant cells, e.g. due to a lack of oxygenation, can be effectively killed with radiation that has a high LET. The LET itself depends on the kinetic energy of the particle, just like the dose, which makes a simultaneous optimization of dose and LET possible only under some circumstances. However, this work presents a method that makes use of the dose ramp concept to beneficially re-distribute areas with high LET using protons, carbon ions and antiprotons, respectively, without notably influencing the dose distribution.\r\nIn the experimental part of this work, a tissue-equivalent proportional counter (TEPC) is used to measure microscopic dose distributions in lineal energy, i.e. fluctuations of the energy concentration on sub-cellular length scales. The extent of these fluctuations as well as the magnitude of the energy concentration have, like the LET, an influence on the biological effect. In the measurements presented here it is assessed if there is a significant change in the dose distributions in lineal energy when comparing two methods of particle beam application to determine a potential impact on the biological effect."^^ . "2013" . . . . . . . "Stefan"^^ . "Sellner"^^ . "Stefan Sellner"^^ . . . . . . "Simulations, Optimizations, and Microdosimetric Measurements of Beam Quality for Heavy-Ion Tumor Therapy. A charged (particle) issue. (PDF)"^^ . . . "Dissertation-Stefan-Sellner.pdf"^^ . . . "Simulations, Optimizations, and Microdosimetric Measurements of Beam Quality for Heavy-Ion Tumor Therapy. A charged (particle) issue. (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Simulations, Optimizations, and Microdosimetric Measurements of Beam Quality for Heavy-Ion Tumor Therapy. A charged (particle) issue. (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Simulations, Optimizations, and Microdosimetric Measurements of Beam Quality for Heavy-Ion Tumor Therapy. A charged (particle) issue. (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Simulations, Optimizations, and Microdosimetric Measurements of Beam Quality for Heavy-Ion Tumor Therapy. A charged (particle) issue. (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Simulations, Optimizations, and Microdosimetric Measurements of Beam Quality for Heavy-Ion Tumor Therapy. A charged (particle) issue. (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #16014 \n\nSimulations, Optimizations, and Microdosimetric Measurements of Beam Quality for Heavy-Ion Tumor Therapy. A charged (particle) issue.\n\n" . "text/html" . . . "500 Naturwissenschaften und Mathematik"@de . "500 Natural sciences and mathematics"@en . . . "530 Physik"@de . "530 Physics"@en . . . "600 Technik, Medizin, angewandte Wissenschaften"@de . "600 Technology (Applied sciences)"@en . .