eprintid: 16198
rev_number: 16
eprint_status: archive
userid: 1017
dir: disk0/00/01/61/98
datestamp: 2014-02-05 08:28:10
lastmod: 2014-02-14 10:39:55
status_changed: 2014-02-05 08:28:10
type: doctoralThesis
metadata_visibility: show
creators_name: Kraus, Kim Melanie
title: Dose Delivery Study for a Novel Compact Proton Accelerator
subjects: ddc-530
subjects: ddc-600
divisions: i-130001
divisions: i-850300
adv_faculty: af-13
abstract: Proton therapy has played an important role in the treatment of cancer with radiation
therapy for more than 60 years. Active spot scanning to deliver highly conformal dose
to the tumor has been developed. However, the availability of proton therapy to the
patients is still limited, partly, due to the high costs and sizes of large proton therapy
centers. Therefore, a novel compact proton single room facility based on a linear accelerator
mounted on a gantry has been proposed, named TULIP (TUrning LInac for
Proton therapy). This accelerator allows for active energy variation on a milliseconds
time scale. This work aims to assess the possibilities of dose delivery with TULIP to exploit
its beneficial features with respect to dose delivery. We developed a software tool,
simulating the dose delivery to the tumor. By means of this software tool, we assessed
different delivery methods and found 3D spot scanning to be superior to rotational dose
delivery with regard to dose and irradiation time. In a second part, we expanded the
investigations to dose delivery to moving targets. Due to fast energy variation, we found
TULIP to be preferably suitable for rescanning, confirmed by irradiation times of only a
few minutes.

date: 2014
id_scheme: DOI
id_number: 10.11588/heidok.00016198
ppn_swb: 1653237740
own_urn: urn:nbn:de:bsz:16-heidok-161983
date_accepted: 2014-01-15
advisor: HASH(0x55fc36ce3730)
language: eng
bibsort: KRAUSKIMMEDOSEDELIVE2014
full_text_status: public
place_of_pub: Heidelberg
citation:   Kraus, Kim Melanie  (2014) Dose Delivery Study for a Novel Compact Proton Accelerator.  [Dissertation]     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/16198/1/Dissertation.pdf