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primary topic: IL-6 induzierte Signaltransduktion in HaCaT-ras A5 und Fibroblasten

IL-6 induzierte Signaltransduktion in HaCaT-ras A5 und Fibroblasten
type: Article
abstract: The interactions between tumor cells and the microenvironment play a crucial role in tumor progression. Tumor cells secrete growth factors, cytokines and proteases and are thus able to affect the gene expression of stromal cells. Activate d stromal cells like fibroblasts, immune cells and endothelial cells are able to promote tumor progression by releasing growth factors, cytokines and proteases. One of the factors which play a central role in this tumor - and stroma - interaction is interleuk in - 6. In many tumor entities, the IL - 6 signal pathway is highly dysregulated by overexpression of IL - 6 and otherwise by permanent activation of the STAT3 transcription factor. In this work, we showed that IL - 6 stimulation resulted in an increased prolifera tion of HaCaT - ras A5 benign tumor keratinocytes, but does not affect the fibroblast cell line MSU1.1. This increase correlates with the activation of the JAK/STAT signaling pathway. We were able to demonstrate that the amount of activated STAT3 proteins after IL - 6 stimulation in HaCaT - ras A5 cells is strongly up regulated and the inhibition of STAT3 activation also inhibits the proliferation of HaCaT - ras A5 cells. This showed the crucial role of the STAT3 activation in proliferation of HaCaT - ras A5 cells. In contrast, fibroblasts showed a stronger inhibition of the JAK/STAT signal pathway by SOCS3 in comparison with the HaCaT - ras A5 cells. All data where used to establish a mathematical model of JAK/STAT pathway which is able to describe the dynamic behav ior of STAT3 and SOCS3 Proteins. In addition to the effects shown, IL - 6 is also able to affect the proliferation in an indirect manner. To this end, IL - 6 stimulation activates a network of growth factors in HaCaT - ras A5 cells and fibroblasts like HGF, KGF , VEGF or IL - 8. While IL - 6 showed no direct influence of the proliferation of fibroblasts, the addition of the condition media of both IL - 6 stimulated HaCaT - ras A5 and as well as IL - 6 st…
date: 2013
author list: authors
type: EPrint
type: DoctoralThesisEPrint
is part of: repository
has document: IL-6 induzierte Signaltransduktion in HaCaT-ras A5 und Fibroblasten (PDF)
has document: IL-6 induzierte Signaltransduktion in HaCaT-ras A5 und Fibroblasten (Other)
subject: 570 Biowissenschaften, Biologie

IL-6 induzierte Signaltransduktion in HaCaT-ras A5 und Fibroblasten (PDF)
type: Document
has file: Dissertation_Marco Nici.pdf
has part: Dissertation_Marco Nici.pdf

Marco Nici
type: Person
given name: Marco
family name: Nici

IL-6 induzierte Signaltransduktion in HaCaT-ras A5 und Fibroblasten (Other)
type: Document
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IL-6 induzierte Signaltransduktion in HaCaT-ras A5 und Fibroblasten (Other)
type: Document
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IL-6 induzierte Signaltransduktion in HaCaT-ras A5 und Fibroblasten (Other)
type: Document
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IL-6 induzierte Signaltransduktion in HaCaT-ras A5 und Fibroblasten (Other)
type: Document
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IL-6 induzierte Signaltransduktion in HaCaT-ras A5 und Fibroblasten (Other)
type: Document
is version of: IL-6 induzierte Signaltransduktion in HaCaT-ras A5 und Fibroblasten (PDF)
is volatile version of: IL-6 induzierte Signaltransduktion in HaCaT-ras A5 und Fibroblasten (PDF)
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primary topic: IL-6 induzierte Signaltransduktion in HaCaT-ras A5 und Fibroblasten

570 Biowissenschaften, Biologie
type: Concept
preferred label: 570 Life sciences @en