<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "A novel combined Structured Illumination and Single Molecule\r\nLocalization Microscope and its application to Retinal Structures"^^ . "Fluorescence microscopy methods have become an major imaging tool in biomedical lifescience. However, each method only addresses specific questions due to intrinsic limitations. A new, fully automated and user-friendly 'Combo'-microscope setup has been developed, which combines the two advanced high-resolution methods Structured Illumination and Localization Microscopy into one imaging system. As both methods complement one another, the 'Combo'-microscope will greatly extend the range of application in biomedical research. Moreover, artifacts, introduced in the course of the imaging and/or reconstruction processes, can be revealed and potential mis-interpretation of super-resolution data is limited.\r\nThis work was motivated by the age-related macular degeneration (AMD), a disease, which is the leading cause of blindness in the Western world. Autofluorescent particles within age-related deposits (drusen) beneath the retinal pigment epithelium are studied on advanced resolution level. Furthermore, the newly built microscope is used for a dual-mode dual-color three-dimensional visualization of the axon initial segment, a crucial region for signal transduction in vision, of retinal ganglion cells. Finally, an in vitro study comparing the pharmaceuticals currently used for AMD-treatment is outlined."^^ . "2014" . . . . . . . "Sabrina"^^ . "Rossberger"^^ . "Sabrina Rossberger"^^ . . . . . . "A novel combined Structured Illumination and Single Molecule\r\nLocalization Microscope and its application to Retinal Structures (PDF)"^^ . . . "PhD_Thesis_SRossberger.pdf"^^ . . . "A novel combined Structured Illumination and Single Molecule\r\nLocalization Microscope and its application to Retinal Structures (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "A novel combined Structured Illumination and Single Molecule\r\nLocalization Microscope and its application to Retinal Structures (Other)"^^ . . . . . . "preview.jpg"^^ . . . "A novel combined Structured Illumination and Single Molecule\r\nLocalization Microscope and its application to Retinal Structures (Other)"^^ . . . . . . "medium.jpg"^^ . . . "A novel combined Structured Illumination and Single Molecule\r\nLocalization Microscope and its application to Retinal Structures (Other)"^^ . . . . . . "small.jpg"^^ . . . "A novel combined Structured Illumination and Single Molecule\r\nLocalization Microscope and its application to Retinal Structures (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #17079 \n\nA novel combined Structured Illumination and Single Molecule \nLocalization Microscope and its application to Retinal Structures\n\n" . "text/html" . . . "530 Physik"@de . "530 Physics"@en . .