<> "The repository administrator has not yet configured an RDF license."^^ . <> . . "Development of Arterial Spin Labeling Techniques for\r\nQuantitative Perfusion Measurements at 3 Tesla"^^ . "Microvascular perfusion is an important parameter of high clinical value as it provides important information on tissue viability and function. In contrast to dynamic contrastenhanced magnetic resonance imaging (DCE-MRI), arterial spin labeling (ASL) is a method to assess quantitative perfusion values non-invasively by MRI. The main goal of this work was the development of a 3D ASL technique that allows the quantitative perfusion measurement within a whole volume. Further, the diagnostic signifcance of ASL was tested by applying it in dedicated renal disease models. ASL yielded significantly (P < 0.01) different values in healthy kidneys ((500+-91) ml/100g/min) compared to kidneys with acute kidney injury ((287+-83) ml/100/min) as well as for acutely rejected transplanted kidneys compared to chronically rejected grafts. A comparison to DCE-MRI showed no signifcant differences. While literature reports on 3D ASL sequences show a prevalence for spin-echo based data acquisitions, the presented sequence employs a 3D balanced steady-state free precession (bSSFP) readout that has the ability to overcome some of the drawbacks of spin-echo based 3D sequences. The developed 3D ASL technique includes several features, each of which has been optimized separately. Special emphasis was put on design, simulation, and implementation of a slice-selective adiabatic inversion pulse. In an initial measurement, the whole-brain perfusion of a healthy volunteer was assessed with an isotropic resolution of 3mm. Mean perfusion values were f_GM = (51+-17) ml/100g/min and f_WM = (24+-8) ml/100/min for gray and white matter, respectively, which are in very good agreement with findings from the \"gold-standard\" method of 15O-positron emission tomography. The diagnostic value of ASL in combination with the possibility to assess absolute perfusion values in a whole volume makes it a promising technique for future clinical diagnosis."^^ . "2014" . . . . . . . "Fabian"^^ . "Zimmer"^^ . "Fabian Zimmer"^^ . . . . . . "Development of Arterial Spin Labeling Techniques for\r\nQuantitative Perfusion Measurements at 3 Tesla (PDF)"^^ . . . "Dissertation_Zimmer.pdf"^^ . . . "Development of Arterial Spin Labeling Techniques for\r\nQuantitative Perfusion Measurements at 3 Tesla (Other)"^^ . . . . . . "indexcodes.txt"^^ . . . "Development of Arterial Spin Labeling Techniques for\r\nQuantitative Perfusion Measurements at 3 Tesla (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Development of Arterial Spin Labeling Techniques for\r\nQuantitative Perfusion Measurements at 3 Tesla (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Development of Arterial Spin Labeling Techniques for\r\nQuantitative Perfusion Measurements at 3 Tesla (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Development of Arterial Spin Labeling Techniques for\r\nQuantitative Perfusion Measurements at 3 Tesla (Other)"^^ . . . . . . "small.jpg"^^ . . "HTML Summary of #17192 \n\nDevelopment of Arterial Spin Labeling Techniques for \nQuantitative Perfusion Measurements at 3 Tesla\n\n" . "text/html" . . . "500 Naturwissenschaften und Mathematik"@de . "500 Natural sciences and mathematics"@en . . . "530 Physik"@de . "530 Physics"@en . . . "600 Technik, Medizin, angewandte Wissenschaften"@de . "600 Technology (Applied sciences)"@en . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .