title: Evaluation of uncertainty in linear energy transfer  calibration of Al2O3:C,Mg-based fluorescent nuclear  track detectors
creator: Mescher, Henning
subject: ddc-530
subject: 530 Physics
description: Fluorescent nuclear track detectors (FNTDs), a novel biocompatible detector type, represent  possible candidates for the application in medical physics research. Besides  recording the particle fluence, they allow for energy deposition quantification, i.e. linear  energy transfer (LET) determination by measuring the fluorescence signal. A correlation  between LET and measured fluorescence intensity was already observed but suffers,  especially concerning the clinical LET range, from large variabilities. Since a precise  relation between those two quantities is still desirable, the aim of this Bachelor’s thesis  was to evaluate different sources of uncertainty regarding the measured fluorescence  intensity. Therefore, a set of 66 detectors was irradiated with mono-energetic particle  beams covering a LET range of 1-150 keV/um . This results in 22 data points with different  LET values consisting of each three irradiated detectors. Intensity measurements were  performed using a commercial confocal laser-scanning microscope. The read out of this  set of detectors enables to investigate microscope and detector related fluctuations. Different  read out days and the read out with different laser powers influence the resulting  fluorescence signals only slightly. Regarding detector related fluctuations, the evaluation  shows decreasing relative intra-image fluctuations related to the stochastic nature of energy  deposition with rising LET. Investigations concerning different read out positions  within the detectors result in relative fluctuations of approximately 4%, whereas relative  inter-detector variabilities are much larger and lie in the magnitude of 16%. Finally, the  measured intensities and the evaluation of the different sources of uncertainty were used  to establish a LET-fluorescence relation.
date: 2014
type: Bachelor thesis
type: info:eu-repo/semantics/bachelorThesis
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/17370/1/BA.pdf
identifier: DOI:10.11588/heidok.00017370
identifier: urn:nbn:de:bsz:16-heidok-173708
identifier:   Mescher, Henning  (2014) Evaluation of uncertainty in linear energy transfer calibration of Al2O3:C,Mg-based fluorescent nuclear track detectors.  [Bachelor thesis]     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/17370/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng