%0 Generic
%A Pryszlak, Anna Marta
%D 2016
%F heidok:17457
%R 10.11588/heidok.00017457
%T Functional Crosstalk between Human Papillomaviruses and Lentiviruses
%U https://archiv.ub.uni-heidelberg.de/volltextserver/17457/
%X Human papillomaviruses (HPVs) and human immunodeficiency virus‐1 (HIV‐1) are human pathogens  of high biomedical significance worldwide. Interestingly, increasing epidemiological evidence  indicates that individuals with active HPV infections possess an enhanced risk of being infected by  HIV‐1. These findings raise the possibility that HPVs may directly or indirectly increase the  pathogenicity of lentiviruses, such as HIV‐1.  Using a Vesicular Stomatitis Virus‐G‐(VSV‐G)‐pseudotyped vector as an experimental model system,  and subsequently extending these analyses to HIV‐1, this study defines a possible scenario which  could account for the epidemiological association between HPV and HIV‐1 infections. These results  provide first insights into the interplay of two important human pathogens which may have profound  clincial implications. Moreover, the findings of this study support the idea that the HPV vaccination  may have a preventive effect against HIV‐1 infections.
%Z The project is patent sensitive