title: Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with Bulimia nervosa and Anorexia nervosa
creator: Müller, Timo D.
creator: Greene, Brandon H.
creator: Bellodi, Laura
creator: Cavallini, Maria C. 
creator: Cellini, Elena
creator: Di Bella, Daniela
creator: Ehrlich, Stefan
creator: Erzegovesi, Stefano
creator: Estivill, Xavier
creator: Fernández-Aranda, Fernando
creator: Fichter, Manfred
creator: Fleischhaker, Christian
creator: Scherag, Susann
creator: Gratacòs, Monica
creator: Grallert, Harald
creator: Herpertz-Dahlmann, Beate
creator: Herzog, Wolfgang
creator: Illig, Thomas
creator: Lehmkuhl, Ulrike
creator: Nacmias, Benedetta
creator: Ribasés, Marta
creator: Ricca, Valdo
creator: Schäfer, Helmut
creator: Scherag, André
creator: Sorbi, Sandro
creator: Wichmann, Heinz-Erich
creator: Hebebrand, Johannes
creator: Hinney, Anke
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Objective: The common single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated gene (FTO) is associated with obesity. As genetic variants associated with weight regulation might also be implicated in the etiology of eating disorders, we evaluated whether SNP rs9939609 is associated with bulimia nervosa (BN) and anorexia nervosa (AN). Methods: Association of rs9939609 with BN and AN was assessed in 689 patients with AN, 477 patients with BN, 984 healthy non-population-based controls, and 3,951 population-based controls (KORA-S4). Based on the familial and premorbid occurrence of obesity in patients with BN, we hypothesized an association of the obesity risk A-allele with BN. Results: In accordance with our hypothesis, we observed evidence for association of the rs9939609 A-allele with BN when compared to the non-population-based controls (unadjusted odds ratio (OR) = 1.142, one-sided 95% confidence interval (CI) 1.001– G ; one-sided p = 0.049) and a trend in the population-based controls (OR = 1.124, one-sided 95% CI 0.932– G ; one-sided  p = 0.056). Interestingly, compared to both control groups, we further detected a nominal association of the rs9939609 A-allele to AN (OR = 1.181, 95% CI 1.027–1.359, two-sided p = 0.020 or OR = 1.673, 95% CI 1.101–2.541, two-sided p = 0.015,). Conclusion: Our data suggest that the obesity-predisposing FTO allele might be relevant in both AN and BN.
publisher: S. Karger AG
date: 2012
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/17792/1/OFA2012005003408.pdf
identifier: DOI:10.11588/heidok.00017792
identifier: urn:nbn:de:bsz:16-heidok-177922
identifier:   Müller, Timo D. ; Greene, Brandon H. ; Bellodi, Laura ; Cavallini, Maria C.  ; Cellini, Elena ; Di Bella, Daniela ; Ehrlich, Stefan ; Erzegovesi, Stefano ; Estivill, Xavier ; Fernández-Aranda, Fernando ; Fichter, Manfred ; Fleischhaker, Christian ; Scherag, Susann ; Gratacòs, Monica ; Grallert, Harald ; Herpertz-Dahlmann, Beate ; Herzog, Wolfgang ; Illig, Thomas ; Lehmkuhl, Ulrike ; Nacmias, Benedetta ; Ribasés, Marta ; Ricca, Valdo ; Schäfer, Helmut ; Scherag, André ; Sorbi, Sandro ; Wichmann, Heinz-Erich ; Hebebrand, Johannes ; Hinney, Anke  (2012) Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with Bulimia nervosa and Anorexia nervosa.  Obesity facts, 5 (3).  pp. 408-419.  ISSN 1662-4025     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/17792/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng