TY  - JOUR
JF  - Obesity facts
TI  - Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with Bulimia nervosa and Anorexia nervosa
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/17792/
A1  - Müller, Timo D.
A1  - Greene, Brandon H.
A1  - Bellodi, Laura
A1  - Cavallini, Maria C. 
A1  - Cellini, Elena
A1  - Di Bella, Daniela
A1  - Ehrlich, Stefan
A1  - Erzegovesi, Stefano
A1  - Estivill, Xavier
A1  - Fernández-Aranda, Fernando
A1  - Fichter, Manfred
A1  - Fleischhaker, Christian
A1  - Scherag, Susann
A1  - Gratacòs, Monica
A1  - Grallert, Harald
A1  - Herpertz-Dahlmann, Beate
A1  - Herzog, Wolfgang
A1  - Illig, Thomas
A1  - Lehmkuhl, Ulrike
A1  - Nacmias, Benedetta
A1  - Ribasés, Marta
A1  - Ricca, Valdo
A1  - Schäfer, Helmut
A1  - Scherag, André
A1  - Sorbi, Sandro
A1  - Wichmann, Heinz-Erich
A1  - Hebebrand, Johannes
A1  - Hinney, Anke
VL  - 5
N2  - Objective: The common single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated gene (FTO) is associated with obesity. As genetic variants associated with weight regulation might also be implicated in the etiology of eating disorders, we evaluated whether SNP rs9939609 is associated with bulimia nervosa (BN) and anorexia nervosa (AN). Methods: Association of rs9939609 with BN and AN was assessed in 689 patients with AN, 477 patients with BN, 984 healthy non-population-based controls, and 3,951 population-based controls (KORA-S4). Based on the familial and premorbid occurrence of obesity in patients with BN, we hypothesized an association of the obesity risk A-allele with BN. Results: In accordance with our hypothesis, we observed evidence for association of the rs9939609 A-allele with BN when compared to the non-population-based controls (unadjusted odds ratio (OR) = 1.142, one-sided 95% confidence interval (CI) 1.001? G ; one-sided p = 0.049) and a trend in the population-based controls (OR = 1.124, one-sided 95% CI 0.932? G ; one-sided
p = 0.056). Interestingly, compared to both control groups, we further detected a nominal association of the rs9939609 A-allele to AN (OR = 1.181, 95% CI 1.027?1.359, two-sided p = 0.020 or OR = 1.673, 95% CI 1.101?2.541, two-sided p = 0.015,). Conclusion: Our data suggest that the obesity-predisposing FTO allele might be relevant in both AN and BN.
SN  - 1662-4025
IS  - 3
PB  - S. Karger AG
Y1  - 2012///
AV  - public
SP  - 408
EP  - 419
ID  - heidok17792
ER  -