eprintid: 17792
rev_number: 142
eprint_status: archive
userid: 1329
dir: disk0/00/01/77/92
datestamp: 2015-01-08 07:49:00
lastmod: 2015-10-31 05:45:06
status_changed: 2015-01-08 07:49:00
type: article
metadata_visibility: show
creators_name: Müller, Timo D.
creators_name: Greene, Brandon H.
creators_name: Bellodi, Laura
creators_name: Cavallini, Maria C. 
creators_name: Cellini, Elena
creators_name: Di Bella, Daniela
creators_name: Ehrlich, Stefan
creators_name: Erzegovesi, Stefano
creators_name: Estivill, Xavier
creators_name: Fernández-Aranda, Fernando
creators_name: Fichter, Manfred
creators_name: Fleischhaker, Christian
creators_name: Scherag, Susann
creators_name: Gratacòs, Monica
creators_name: Grallert, Harald
creators_name: Herpertz-Dahlmann, Beate
creators_name: Herzog, Wolfgang
creators_name: Illig, Thomas
creators_name: Lehmkuhl, Ulrike
creators_name: Nacmias, Benedetta
creators_name: Ribasés, Marta
creators_name: Ricca, Valdo
creators_name: Schäfer, Helmut
creators_name: Scherag, André
creators_name: Sorbi, Sandro
creators_name: Wichmann, Heinz-Erich
creators_name: Hebebrand, Johannes
creators_name: Hinney, Anke
title: Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with Bulimia nervosa and Anorexia nervosa
subjects: ddc-610
divisions: i-910700
cterms_swd: Essstörung
cterms_swd: Anorexia nervosa
cterms_swd: Bulimie
abstract: Objective: The common single nucleotide polymorphism (SNP) rs9939609 in the fat mass and obesity-associated gene (FTO) is associated with obesity. As genetic variants associated with weight regulation might also be implicated in the etiology of eating disorders, we evaluated whether SNP rs9939609 is associated with bulimia nervosa (BN) and anorexia nervosa (AN). Methods: Association of rs9939609 with BN and AN was assessed in 689 patients with AN, 477 patients with BN, 984 healthy non-population-based controls, and 3,951 population-based controls (KORA-S4). Based on the familial and premorbid occurrence of obesity in patients with BN, we hypothesized an association of the obesity risk A-allele with BN. Results: In accordance with our hypothesis, we observed evidence for association of the rs9939609 A-allele with BN when compared to the non-population-based controls (unadjusted odds ratio (OR) = 1.142, one-sided 95% confidence interval (CI) 1.001– G ; one-sided p = 0.049) and a trend in the population-based controls (OR = 1.124, one-sided 95% CI 0.932– G ; one-sided
p = 0.056). Interestingly, compared to both control groups, we further detected a nominal association of the rs9939609 A-allele to AN (OR = 1.181, 95% CI 1.027–1.359, two-sided p = 0.020 or OR = 1.673, 95% CI 1.101–2.541, two-sided p = 0.015,). Conclusion: Our data suggest that the obesity-predisposing FTO allele might be relevant in both AN and BN.
date: 2012
publisher: S. Karger AG
id_scheme: DOI
id_number: 10.11588/heidok.00017792
ppn_swb: 1654927546
own_urn: urn:nbn:de:bsz:16-heidok-177922
language: eng
bibsort: MULLERTIMOFATMASSAND2012
full_text_status: public
publication: Obesity facts
volume: 5
number: 3
pagerange: 408-419
issn: 1662-4025
citation:   Müller, Timo D. ; Greene, Brandon H. ; Bellodi, Laura ; Cavallini, Maria C.  ; Cellini, Elena ; Di Bella, Daniela ; Ehrlich, Stefan ; Erzegovesi, Stefano ; Estivill, Xavier ; Fernández-Aranda, Fernando ; Fichter, Manfred ; Fleischhaker, Christian ; Scherag, Susann ; Gratacòs, Monica ; Grallert, Harald ; Herpertz-Dahlmann, Beate ; Herzog, Wolfgang ; Illig, Thomas ; Lehmkuhl, Ulrike ; Nacmias, Benedetta ; Ribasés, Marta ; Ricca, Valdo ; Schäfer, Helmut ; Scherag, André ; Sorbi, Sandro ; Wichmann, Heinz-Erich ; Hebebrand, Johannes ; Hinney, Anke  (2012) Fat mass and obesity-associated gene (FTO) in eating disorders: evidence for association of the rs9939609 obesity risk allele with Bulimia nervosa and Anorexia nervosa.  Obesity facts, 5 (3).  pp. 408-419.  ISSN 1662-4025     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/17792/1/OFA2012005003408.pdf