eprintid: 17794
rev_number: 52
eprint_status: archive
userid: 1329
dir: disk0/00/01/77/94
datestamp: 2015-01-08 08:11:24
lastmod: 2016-01-15 13:58:44
status_changed: 2015-01-08 08:11:24
type: article
metadata_visibility: show
creators_name: Mutschler, Jochen
creators_name: Abbruzzese, Elvira
creators_name: Goltz, Christoph von der
creators_name: Dinter, Christina
creators_name: Mobascher, Arian
creators_name: Thiele, Holger
creators_name: Diaz-Lacava, Amalia
creators_name: Dahmen, Norbert
creators_name: Gallinat, Jürgen
creators_name: Majic, Tomislav
creators_name: Petrovsky, Nadine
creators_name: Kornhuber, Johannes
creators_name: Thürauf, Norbert
creators_name: Gründer, Gerhard
creators_name: Brinkmeyer, Jürgen
creators_name: Wienker, Thomas
creators_name: Wagner, Michael
creators_name: Winterer, Georg
creators_name: Kiefer, Falk
title: Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking
subjects: ddc-610
divisions: i-851200
cterms_swd: Neuropeptid Y
cterms_swd: Polymorphismus
cterms_swd: Nicotin
cterms_swd: Tabak
cterms_swd: Rauchen
cterms_swd: Genetik
abstract: Background: Neuropeptide Y (NPY) is a strong candidate gene regarding the pathophysiology of tobacco dependence. It has been associated with various addictive and psychiatric disorders, and closely interacts with the brain reward system. The aim of the present study was to test for association between a functional genetic variant in the NP-Y promoter gene (SNP rs16147) and tobacco smoking. Methods: In a population-based case-control multicenter study designed for tobacco addiction research, a total of 550 Caucasian current smokers, and 544 never-smokers were genotyped for SNP rs16147 and behaviorally characterized with the State-Trait Anxiety Inventory (STAI). Results: Subjects with TT genotype of the SNP rs16147 were significantly more frequently smokers than never-smokers (p = 0.046). In addition, TT genotype exhibited increased state anxiety scores compared to carriers of the C allele (p = 0.037). Conclusions: Our results provide evidence for an involvement of the functionally relevant SNP rs16147 in the pathophysiology of tobacco dependence. Further studies are needed to confirm our findings.
date: 2012
publisher: S. Karger AG
id_scheme: DOI
id_number: 10.11588/heidok.00017794
ppn_swb: 1654881643
own_urn: urn:nbn:de:bsz:16-heidok-177946
language: eng
bibsort: MUTSCHLERJGENETICVAR2012
full_text_status: public
publication: European addiction research
volume: 18
number: 5
pagerange: 246-252
issn: 1022-6877
citation:   Mutschler, Jochen ; Abbruzzese, Elvira ; Goltz, Christoph von der ; Dinter, Christina ; Mobascher, Arian ; Thiele, Holger ; Diaz-Lacava, Amalia ; Dahmen, Norbert ; Gallinat, Jürgen ; Majic, Tomislav ; Petrovsky, Nadine ; Kornhuber, Johannes ; Thürauf, Norbert ; Gründer, Gerhard ; Brinkmeyer, Jürgen ; Wienker, Thomas ; Wagner, Michael ; Winterer, Georg ; Kiefer, Falk  (2012) Genetic variation in the neuropeptide Y gene promoter is associated with increased risk of tobacco smoking.  European addiction research, 18 (5).  pp. 246-252.  ISSN 1022-6877     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/17794/1/EAR2012018005246.pdf