TY  - JOUR
PB  - S. Karger AG
SN  - 1015-9770
AV  - public
ID  - heidok17801
A1  - Rizos, Timolaos
A1  - Horstmann, Solveig
A1  - Jenetzky, Ekkehart
A1  - Spindler, Marcia
A1  - Gumbinger, Christoph
A1  - Möhlenbruch, Markus
A1  - Ringleb, Peter
A1  - Hacke, Werner
A1  - Veltkamp, Roland
IS  - 5-6
SP  - 411
TI  - Oral anticoagulants - a frequent challenge for the emergency management of acute ischemic stroke
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/17801/
JF  - Cerebrovascular diseases
N2  - Background: The emergency management of patients with acute ischemic stroke (IS) using oral anticoagulants (OAC) represents a great challenge. Effective anticoagulation predisposes to bleeding and represents a contraindication for systemic thrombolysis. However, patients on OAC can receive intravenous thrombolysis with recombinant tissue-type plasminogen activator if the international normalized ratio (INR) does not exceed 1.7, but data regarding the risk of hemorrhagic complications are highly controversial. Neurointerventional recanalization of intracranial artery occlusion represents an alternative option in OAC patients with acute IS. The proportion of OAC users among consecutive patients who suffer from acute IS or transient ichemic attacks (TIA) is unknown. Methods: A prospective observational study, consecutively enrolling all patients with IS or TIA admitted to our neurological emergency room (ER), was performed between August 2009 and February 2011. Basic demographic variables, present use of OAC, severity of stroke, cardiovascular risk factors, INR values and the symptom onset to presentation time were recorded. In IS patients on OAC presenting within 4.5 h after symptom onset, management was analyzed. In thrombolysed IS patients, bleeding events were documented. Outcome was assessed after 3 months.
EP  - 418
Y1  - 2012///
VL  - 34
ER  -