eprintid: 17801
rev_number: 34
eprint_status: archive
userid: 1329
dir: disk0/00/01/78/01
datestamp: 2015-01-08 09:34:25
lastmod: 2016-01-17 14:35:52
status_changed: 2015-01-08 09:34:25
type: article
metadata_visibility: show
creators_name: Rizos, Timolaos
creators_name: Horstmann, Solveig
creators_name: Jenetzky, Ekkehart
creators_name: Spindler, Marcia
creators_name: Gumbinger, Christoph
creators_name: Möhlenbruch, Markus
creators_name: Ringleb, Peter
creators_name: Hacke, Werner
creators_name: Veltkamp, Roland
title: Oral anticoagulants - a frequent challenge for the emergency management of acute ischemic stroke
subjects: ddc-610
divisions: i-911100
abstract: Background: The emergency management of patients with acute ischemic stroke (IS) using oral anticoagulants (OAC) represents a great challenge. Effective anticoagulation predisposes to bleeding and represents a contraindication for systemic thrombolysis. However, patients on OAC can receive intravenous thrombolysis with recombinant tissue-type plasminogen activator if the international normalized ratio (INR) does not exceed 1.7, but data regarding the risk of hemorrhagic complications are highly controversial. Neurointerventional recanalization of intracranial artery occlusion represents an alternative option in OAC patients with acute IS. The proportion of OAC users among consecutive patients who suffer from acute IS or transient ichemic attacks (TIA) is unknown. Methods: A prospective observational study, consecutively enrolling all patients with IS or TIA admitted to our neurological emergency room (ER), was performed between August 2009 and February 2011. Basic demographic variables, present use of OAC, severity of stroke, cardiovascular risk factors, INR values and the symptom onset to presentation time were recorded. In IS patients on OAC presenting within 4.5 h after symptom onset, management was analyzed. In thrombolysed IS patients, bleeding events were documented. Outcome was assessed after 3 months.
date: 2012
publisher: S. Karger AG
id_scheme: DOI
id_number: 10.11588/heidok.00017801
ppn_swb: 1654893528
own_urn: urn:nbn:de:bsz:16-heidok-178016
language: eng
bibsort: RIZOSTIMOLORALANTICO2012
full_text_status: public
publication: Cerebrovascular diseases
volume: 34
number: 5-6
pagerange: 411-418
issn: 1015-9770
citation:   Rizos, Timolaos ; Horstmann, Solveig ; Jenetzky, Ekkehart ; Spindler, Marcia ; Gumbinger, Christoph ; Möhlenbruch, Markus ; Ringleb, Peter ; Hacke, Werner ; Veltkamp, Roland  (2012) Oral anticoagulants - a frequent challenge for the emergency management of acute ischemic stroke.  Cerebrovascular diseases, 34 (5-6).  pp. 411-418.  ISSN 1015-9770     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/17801/1/CED20120345-6411.pdf