eprintid: 17809
rev_number: 13
eprint_status: archive
userid: 1329
dir: disk0/00/01/78/09
datestamp: 2014-12-22 07:49:16
lastmod: 2015-01-31 19:50:08
status_changed: 2014-12-22 07:49:16
type: article
metadata_visibility: show
creators_name: Ullrich, Heiko
creators_name: Kranaster, Laura
creators_name: Sigges, Erich
creators_name: Andrich, Jürgen
creators_name: Sartorius, Alexander
title: Ultra-high-frequency left prefrontal transcranial magnetic stimulation as augmentation in severely ill patients with depression: a naturalistic sham-controlled, double-blind, randomized trial
subjects: ddc-610
divisions: i-851200
abstract: Background and Aim: Repetitive transcranial magnetic stimulation (rTMS) is supposed to be not as effective in severe depression as it is in medium depression. We evaluated the treatment response to an ultra-high-frequency (UHF; 30 Hz) approach, which was used to maximize the rTMS efficacy in severely ill patients. Methods: 43 severely depressed patients were included in the randomized, double-blind study and received either rTMS with 30 Hz over the left dorsolateral prefrontal cortex or sham condition for 3 weeks as an add-on therapy to stable antidepressant medication. Hamilton Depression Rating Scale (HDRS) and cognitive performance were evaluated before and after the intervention. Results: In the active UHF group, the HRDS score was reduced by about 7.2, whereas the sham condition showed a smaller reduction of the HDRS score with 3.9. However, lithium as a covariant was responsible for the outcome difference, not the group of stimulation. No adverse events were reported. Comparing the differences of both groups in the pre- and post-study performance in a trail-making test, a group effect for the UHF group that was not influenced by the lithium intake was observed. Conclusion: A 30-Hz left prefrontal rTMS in severely depressed patients was safe and no adverse events occurred. Due to a strong effect of lithium as a covariate, we could not demonstrate favorable antidepressant effects of the UHF stimulation compared to sham. However, we found an improvement of processing speed performance in the UHF group, which covaried with improvement of psychomotor retardation. Copyright (C) 2012 S. Karger AG, Basel
date: 2012
publisher: S. Karger AG
id_scheme: DOI
id_number: 10.11588/heidok.00017809
ppn_swb: 1654688371
own_urn: urn:nbn:de:bsz:16-heidok-178092
language: eng
bibsort: ULLRICHHEIULTRAHIGHF2012
full_text_status: public
publication: Neuropsychobiology
volume: 66
number: 3
pagerange: 141-148
issn: 0302-282X
citation:   Ullrich, Heiko ; Kranaster, Laura ; Sigges, Erich ; Andrich, Jürgen ; Sartorius, Alexander  (2012) Ultra-high-frequency left prefrontal transcranial magnetic stimulation as augmentation in severely ill patients with depression: a naturalistic sham-controlled, double-blind, randomized trial.  Neuropsychobiology, 66 (3).  pp. 141-148.  ISSN 0302-282X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/17809/1/NPS2012066003141.pdf