eprintid: 17818
rev_number: 25
eprint_status: archive
userid: 1329
dir: disk0/00/01/78/18
datestamp: 2015-01-12 13:07:10
lastmod: 2016-01-06 05:03:47
status_changed: 2015-01-12 13:07:10
type: article
metadata_visibility: show
creators_name: Bergler, Tobias
creators_name: Hoffmann, Ute
creators_name: Bergler, Elisabeth
creators_name: Jung, Bettina
creators_name: Banas, Miriam C.
creators_name: Reinhold, Stephan W.
creators_name: Krämer, Bernhard K.
creators_name: Banas, Bernhard
title: Toll-like receptor 4 in experimental kidney transplantation: early mediator of endogenous danger signals
subjects: ddc-610
divisions: i-62600
cterms_swd: Chemokine
cterms_swd: Fibrinogen
cterms_swd: Angeborene Immunität
cterms_swd: Makrophage
abstract: The role of toll-like receptors (TLRs) has been described in the pathogenesis of renal ischemia/reperfusion injury, but data on the expression and function of TLR4 during renal allograft damage are still scarce. We analyzed the expression of TLR4 in an experimental rat model 6 and 28 days after allogeneic kidney transplantation in comparison to control rats and rats after syngeneic transplantation. On day 6, a significant induction in TLR4 expression - restricted to the glomerular compartment - was found in acute rejecting allografts only. TLR4 expression strongly correlated with renal function, and TLR4 induction was accompanied by a significant increase in CC chemokine expression within the graft as well as in urinary CC chemokine excretion. TLR4 induction may be caused by an influx of macrophages as well as TLR4-expressing intrinsic renal cells. Fibrinogen deposition in renal allografts correlated with renal TLR4 expression and may act as a potent stimulator of chemokine release via TLR4 activation. This study provides, for the first time, data about the precise intrarenal localization and TLR4 induction after experimental kidney transplantation. It supports the hypothesis that local TLR4 activation by endogenous ligands may be one pathological link from unspecific primary allograft damage to subsequent chemokine release, infiltration and activation of immune cells leading to deterioration of renal function and induction of renal fibrosis. Copyright (c) 2012 S. Karger AG, Basel
date: 2012
publisher: S. Karger AG
id_scheme: DOI
id_number: 10.11588/heidok.00017818
ppn_swb: 1654938068
own_urn: urn:nbn:de:bsz:16-heidok-178180
language: eng
bibsort: BERGLERTOBTOLLLIKERE2012
full_text_status: public
publication: Nephron experimental nephrology
volume: 121
number: 3-4
pagerange: E59-E70
issn: 1660-2129
citation:   Bergler, Tobias ; Hoffmann, Ute ; Bergler, Elisabeth ; Jung, Bettina ; Banas, Miriam C. ; Reinhold, Stephan W. ; Krämer, Bernhard K. ; Banas, Bernhard  (2012) Toll-like receptor 4 in experimental kidney transplantation: early mediator of endogenous danger signals.  Nephron experimental nephrology, 121 (3-4).  E59-E70.  ISSN 1660-2129     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/17818/1/NEE20121213-4e59.pdf