title: Promotion of hepatocellular carcinoma by hepatitis C virus
creator: Bühler, Sandra
creator: Bartenschlager, Ralf
subject: ddc-610
subject: 610 Medical sciences Medicine
description: Persistent infection with the hepatitis C virus (HCV) is a major global health problem. Around 2-3% of the world’s population are chronically infected, and infected individuals are at high risk of developing steatosis, fibrosis, and liver cirrhosis. The latter is a major predisposing factor for the development of hepatocellular carcinoma (HCC). It is generally accepted that an inflammatory response triggered by persistent HCV infection leads to increased cell proliferation and fibrogenesis that in turn promotes cirrhosis and ultimately HCC development. This indirect mechanism of tumor induction would explain the long incubation period from primary HCV infection to HCC and the requirement for additional cofactors such as toxins or drugs (most notably alcohol), metabolic liver diseases, steatosis, nonalcoholic liver disease, or diabetes. With the advent of adequate cell culture systems for HCV it is, however, becoming increasingly clear that the virus also contributes directly to HCC formation. Examples are the continuous induction of stress response or the massive accumulation of intracellular lipids. Moreover, viral proteins can bind to and sequester cell cycle control factors such as the retinoblastoma protein or the tumor suppressor DDX3. Thus, HCV-associated liver cancer is most likely promoted by the combined action of long-term chronic inflammation and targeted perturbations of cellular key pathways involved in metabolic homeostasis as well as cell cycle control. Copyright (c) 2012 S. Karger AG, Basel
publisher: S. Karger AG
date: 2012
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/17819/1/DDI2012030005445.pdf
identifier: DOI:10.11588/heidok.00017819
identifier: urn:nbn:de:bsz:16-heidok-178194
identifier:   Bühler, Sandra ; Bartenschlager, Ralf  (2012) Promotion of hepatocellular carcinoma by hepatitis C virus.  Digestive diseases, 30 (5).  pp. 445-452.  ISSN 0257-2753     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/17819/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng