<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Alzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit"^^ . "Background: The pathogenesis of Alzheimer’s disease (AD) is characterized by neuronal injury, activation of microglia and astrocytes, deposition of amyloid-beta and secondary vessel degeneration. In the polycystic kidney disease (PKD) rat model, we observed neuronal injury, microglial activation and vasoregression. We speculated that this neuroretinal degeneration shares important pathogenetic steps with AD. Therefore, we determined the activation of astrocytes and the accumulation of amyloid-beta in PKD retinae. Methods: Immunohistochemistry of PKD retinae for vimentin, carboxymethyllysin, beta-Amyloid 1-42, High-Mobility-Group-Protein B1 and amyloid protein precursor was performed. Results: Adjunct to astrocyte activation, accumulation of beta-Amyloid 1-42 and High-Mobility-Group-Protein B1 in astrocytes and around vessels of the superficial network was found in PKD retinae prior to the onset of vasoregression. Amyloid precursor protein was localized adjacent to the outer segment of photoreceptors in PKD and control rats. The parallel appearance of AD-related peptides indicates an alarmine based response to photoreceptor degeneration and secondary vasoregression. Conclusion: The model has broad overlap with AD and may be suitable to study beneficial pharmacological concepts. Copyright (c) 2012 S. Karger AG, Basel"^^ . "2012" . . . "30" . "6" . . "S. Karger AG"^^ . . . "Cellular physiology and biochemistry"^^ . . . "10158987" . . . . . . . . . . . . . . . . . . . . "Hans-Peter"^^ . "Hammes"^^ . "Hans-Peter Hammes"^^ . . "Liang"^^ . "Wu"^^ . "Liang Wu"^^ . . "Norbert"^^ . "Gretz"^^ . "Norbert Gretz"^^ . . "Stephanie"^^ . "Busch"^^ . "Stephanie Busch"^^ . . "Yuxi"^^ . "Feng"^^ . "Yuxi Feng"^^ . . "Sigrid"^^ . "Hoffmann"^^ . "Sigrid Hoffmann"^^ . . . . . . "Alzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit (PDF)"^^ . . . "CPB20120300061436.pdf"^^ . . . "Alzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Alzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Alzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Alzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit (Other)"^^ . . . . . . "small.jpg"^^ . . . "Alzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #17820 \n\nAlzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .