TY  - JOUR
TI  - Alzheimer?s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit
EP  - 1443
PB  - S. Karger AG
SP  - 1436
SN  - 1015-8987
IS  - 6
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/17820/
N2  - Background: The pathogenesis of Alzheimer?s disease (AD) is characterized by neuronal injury, activation of microglia and astrocytes, deposition of amyloid-beta and secondary vessel degeneration. In the polycystic kidney disease (PKD) rat model, we observed neuronal injury, microglial activation and vasoregression. We speculated that this neuroretinal degeneration shares important pathogenetic steps with AD. Therefore, we determined the activation of astrocytes and the accumulation of amyloid-beta in PKD retinae. Methods: Immunohistochemistry of PKD retinae for vimentin, carboxymethyllysin, beta-Amyloid 1-42, High-Mobility-Group-Protein B1 and amyloid protein precursor was performed. Results: Adjunct to astrocyte activation, accumulation of beta-Amyloid 1-42 and High-Mobility-Group-Protein B1 in astrocytes and around vessels of the superficial network was found in PKD retinae prior to the onset of vasoregression. Amyloid precursor protein was localized adjacent to the outer segment of photoreceptors in PKD and control rats. The parallel appearance of AD-related peptides indicates an alarmine based response to photoreceptor degeneration and secondary vasoregression. Conclusion: The model has broad overlap with AD and may be suitable to study beneficial pharmacological concepts. Copyright (c) 2012 S. Karger AG, Basel
VL  - 30
A1  - Busch, Stephanie
A1  - Wu, Liang
A1  - Feng, Yuxi
A1  - Gretz, Norbert
A1  - Hoffmann, Sigrid
A1  - Hammes, Hans-Peter
ID  - heidok17820
AV  - public
Y1  - 2012///
JF  - Cellular physiology and biochemistry
ER  -