eprintid: 17820
rev_number: 20
eprint_status: archive
userid: 1329
dir: disk0/00/01/78/20
datestamp: 2015-01-12 13:19:08
lastmod: 2016-01-11 11:00:13
status_changed: 2015-01-12 13:19:08
type: article
metadata_visibility: show
creators_name: Busch, Stephanie
creators_name: Wu, Liang
creators_name: Feng, Yuxi
creators_name: Gretz, Norbert
creators_name: Hoffmann, Sigrid
creators_name: Hammes, Hans-Peter
title: Alzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit
subjects: ddc-610
divisions: i-61002
divisions: i-61900
cterms_swd: Alzheimer-Krankheit
cterms_swd: Retinopathie
abstract: Background: The pathogenesis of Alzheimer’s disease (AD) is characterized by neuronal injury, activation of microglia and astrocytes, deposition of amyloid-beta and secondary vessel degeneration. In the polycystic kidney disease (PKD) rat model, we observed neuronal injury, microglial activation and vasoregression. We speculated that this neuroretinal degeneration shares important pathogenetic steps with AD. Therefore, we determined the activation of astrocytes and the accumulation of amyloid-beta in PKD retinae. Methods: Immunohistochemistry of PKD retinae for vimentin, carboxymethyllysin, beta-Amyloid 1-42, High-Mobility-Group-Protein B1 and amyloid protein precursor was performed. Results: Adjunct to astrocyte activation, accumulation of beta-Amyloid 1-42 and High-Mobility-Group-Protein B1 in astrocytes and around vessels of the superficial network was found in PKD retinae prior to the onset of vasoregression. Amyloid precursor protein was localized adjacent to the outer segment of photoreceptors in PKD and control rats. The parallel appearance of AD-related peptides indicates an alarmine based response to photoreceptor degeneration and secondary vasoregression. Conclusion: The model has broad overlap with AD and may be suitable to study beneficial pharmacological concepts. Copyright (c) 2012 S. Karger AG, Basel
date: 2012
publisher: S. Karger AG
id_scheme: DOI
id_number: 10.11588/heidok.00017820
ppn_swb: 1655567241
own_urn: urn:nbn:de:bsz:16-heidok-178203
language: eng
bibsort: BUSCHSTEPHALZHEIMERS2012
full_text_status: public
publication: Cellular physiology and biochemistry
volume: 30
number: 6
pagerange: 1436-1443
issn: 1015-8987
citation:   Busch, Stephanie ; Wu, Liang ; Feng, Yuxi ; Gretz, Norbert ; Hoffmann, Sigrid ; Hammes, Hans-Peter  (2012) Alzheimer’s disease and retinal neurodegeneration share a consistent stress response of the neurovascular unit.  Cellular physiology and biochemistry, 30 (6).  pp. 1436-1443.  ISSN 1015-8987     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/17820/1/CPB20120300061436.pdf