<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Molecular analysis of desmoid tumors with a high-density single-nucleotide polymorphism array identifies new molecular candidate lesions"^^ . "Background: Desmoid tumors are neoplastic proliferations of connective tissues. The mutation status of the gene coding for catenin (cadherin-associated protein) beta 1 (CTNNB1) and trisomy 8 on the chromosomal level have been described to have prognostic relevance. Patients and Methods: In order to elucidate new molecular mechanisms underlying these tumors, we carried out a molecular analysis with a genome-wide human high-density single-nucleotide polymorphism (SNP) array, in 9 patients. Results: Single samples showed numerical aberrations on chromosomes (Chrs) 20 and 6 with either trisomy 20 or monosomy 6. No trisomy 8 could be detected. Recurrent heterozygous deletions were found in Chr 5q (including the APC gene locus, n = 3) and Chr 8p23 (n = 4, containing coding regions for the potential tumor suppressor gene CSMD1). This novel deletion in 8p23 showed an association with local recurrence. In addition, structural chromosomal changes (gain of Chrs 8 and 20) were found in a minority of cases. Conclusion: The genomic alteration affecting the candidate gene CSMD1 could be important in the development of desmoid tumors."^^ . "2012" . . . "35" . "11" . . "S. Karger AG"^^ . . . "Onkologie"^^ . . . "0378584X" . . . . . . . . . . . . . . . . . . . . . . . . . . "Philipp"^^ . "Ströbel"^^ . "Philipp Ströbel"^^ . . "Philipp"^^ . "Erben"^^ . "Philipp Erben"^^ . . "Bernd"^^ . "Kasper"^^ . "Bernd Kasper"^^ . . "Peter"^^ . "Hohenberger"^^ . "Peter Hohenberger"^^ . . "Wolf-Karsten"^^ . "Hofmann"^^ . "Wolf-Karsten Hofmann"^^ . . "Daniel"^^ . "Nowak"^^ . "Daniel Nowak"^^ . . "Ralf-Dieter"^^ . "Hofheinz"^^ . "Ralf-Dieter Hofheinz"^^ . . "Christian"^^ . "Sauer"^^ . "Christian Sauer"^^ . . . . . . "Molecular analysis of desmoid tumors with a high-density single-nucleotide polymorphism array identifies new molecular candidate lesions (PDF)"^^ . . . "ONK2012035011684.pdf"^^ . . . "Molecular analysis of desmoid tumors with a high-density single-nucleotide polymorphism array identifies new molecular candidate lesions (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Molecular analysis of desmoid tumors with a high-density single-nucleotide polymorphism array identifies new molecular candidate lesions (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Molecular analysis of desmoid tumors with a high-density single-nucleotide polymorphism array identifies new molecular candidate lesions (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Molecular analysis of desmoid tumors with a high-density single-nucleotide polymorphism array identifies new molecular candidate lesions (Other)"^^ . . . . . . "small.jpg"^^ . . . "Molecular analysis of desmoid tumors with a high-density single-nucleotide polymorphism array identifies new molecular candidate lesions (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #17825 \n\nMolecular analysis of desmoid tumors with a high-density single-nucleotide polymorphism array identifies new molecular candidate lesions\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .