<> "The repository administrator has not yet configured an RDF license."^^ . <> . . . "Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula"^^ . "Introduction: According to the neurotrophin hypothesis, a brain-derived neurotrophic factor (BDNF) decrease has been postulated as a pivotal pathomechanism in affective disorder, and the treatment-associated increase in peripheral BDNF has been linked to therapeutic efficacy of antidepressant drugs and electroconvulsive therapy. However, in deep brain stimulation (DBS), a still experimental antidepressant treatment approach, this issue has not yet been investigated. Methods: We examine the long-term course of serum BDNF levels in a 64-year-old woman who is being treated with DBS of the lateral habenula for severe major depressive disorder. Results: Our main findings are a significant increase in BDNF serum levels following DBS of the lateral habenula and an inverse U-shaped correlation of depression scores and BDNF levels. Discussion: The data indicate that DBS, like other effective antidepressant treatments, may contribute to an increase in peripheral BDNF levels, which are thought to reflect central nervous DBS-induced neuroplastic changes. Moreover, our observations underscore the complex nature of disease-associated BDNF alterations. Their identification as either state or trait marker remains controversial and requires larger-scale longitudinal studies. Copyright (C) 2012 S. Karger AG, Basel"^^ . "2012" . . . "65" . "3" . . "S. Karger AG"^^ . . . "Neuropsychobiology"^^ . . . "0302282X" . . . . . . . . . . . . . . . . . "Alexander"^^ . "Sartorius"^^ . "Alexander Sartorius"^^ . . "Peter"^^ . "Gass"^^ . "Peter Gass"^^ . . "Rainer"^^ . "Hellweg"^^ . "Rainer Hellweg"^^ . . "Carolin"^^ . "Hoyer"^^ . "Carolin Hoyer"^^ . . "Laura"^^ . "Kranaster"^^ . "Laura Kranaster"^^ . . . . . . "Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula (PDF)"^^ . . . "NPS2012065003147.pdf"^^ . . . "Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula (Other)"^^ . . . . . . "lightbox.jpg"^^ . . . "Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula (Other)"^^ . . . . . . "preview.jpg"^^ . . . "Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula (Other)"^^ . . . . . . "medium.jpg"^^ . . . "Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula (Other)"^^ . . . . . . "small.jpg"^^ . . . "Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula (Other)"^^ . . . . . . "indexcodes.txt"^^ . . "HTML Summary of #17840 \n\nLong-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula\n\n" . "text/html" . . . "610 Medizin"@de . "610 Medical sciences Medicine"@en . .