eprintid: 17840
rev_number: 13
eprint_status: archive
userid: 1329
dir: disk0/00/01/78/40
datestamp: 2014-12-11 08:09:58
lastmod: 2015-01-24 20:41:30
status_changed: 2014-12-11 08:09:58
type: article
metadata_visibility: show
creators_name: Hoyer, Carolin
creators_name: Kranaster, Laura
creators_name: Sartorius, Alexander
creators_name: Hellweg, Rainer
creators_name: Gass, Peter
title: Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula
subjects: ddc-610
divisions: i-851200
abstract: Introduction: According to the neurotrophin hypothesis, a brain-derived neurotrophic factor (BDNF) decrease has been postulated as a pivotal pathomechanism in affective disorder, and the treatment-associated increase in peripheral BDNF has been linked to therapeutic efficacy of antidepressant drugs and electroconvulsive therapy. However, in deep brain stimulation (DBS), a still experimental antidepressant treatment approach, this issue has not yet been investigated. Methods: We examine the long-term course of serum BDNF levels in a 64-year-old woman who is being treated with DBS of the lateral habenula for severe major depressive disorder. Results: Our main findings are a significant increase in BDNF serum levels following DBS of the lateral habenula and an inverse U-shaped correlation of depression scores and BDNF levels. Discussion: The data indicate that DBS, like other effective antidepressant treatments, may contribute to an increase in peripheral BDNF levels, which are thought to reflect central nervous DBS-induced neuroplastic changes. Moreover, our observations underscore the complex nature of disease-associated BDNF alterations. Their identification as either state or trait marker remains controversial and requires larger-scale longitudinal studies. Copyright (C) 2012 S. Karger AG, Basel
date: 2012
publisher: S. Karger AG
id_scheme: DOI
id_number: 10.11588/heidok.00017840
ppn_swb: 1654624616
own_urn: urn:nbn:de:bsz:16-heidok-178407
language: eng
bibsort: HOYERCAROLLONGTERMCO2012
full_text_status: public
publication: Neuropsychobiology
volume: 65
number: 3
pagerange: 147-152
issn: 0302-282X
citation:   Hoyer, Carolin ; Kranaster, Laura ; Sartorius, Alexander ; Hellweg, Rainer ; Gass, Peter  (2012) Long-term course of brain-derived neurotrophic factor serum levels in a patient treated with deep brain stimulation of the lateral habenula.  Neuropsychobiology, 65 (3).  pp. 147-152.  ISSN 0302-282X     
document_url: https://archiv.ub.uni-heidelberg.de/volltextserver/17840/1/NPS2012065003147.pdf