title: Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer
creator: Kamphues, Carsten
creator: Wittschieber, Daniel
creator: Klauschen, Frederick
creator: Kasajima, Atsuko
creator: Dietel, Manfred
creator: Schmidt, Sven-Christian
creator: Glanemann, Matthias
creator: Bahra, Marcus
creator: Neuhaus, Peter
creator: Weichert, Wilko
creator: Stenzinger, Albrecht
subject: 610
subject: 610 Medical sciences Medicine
description: Objective: According to recent research, prolyl hydroxylase domain 2 protein (PHD2) plays an important role in human carcinogenesis by inducing neovascularization and tumor growth. The aim of this study was to evaluate PHD2 expression patterns in primary gastric adenocarcinoma and to test for a potential predictive value of PHD2 expression in gastric cancer patients. Methods: In a total of 121 patients, PHD2 expression was investigated by immunohistochemistry in paraffin- embedded tissue and correlated with clinicopathological parameters and patient survival. Results: 64 of 121 gastric carcinomas (52.9%) showed PHD2 expression in tumor cell cytoplasm. In univariate analysis, PHD2- negative patients had a significantly shortened survival in comparison
publisher: S. Karger AG
date: 2012
type: Article
type: info:eu-repo/semantics/article
type: NonPeerReviewed
format: application/pdf
identifier: https://archiv.ub.uni-heidelberg.de/volltextserverhttps://archiv.ub.uni-heidelberg.de/volltextserver/17841/1/PAT2012079001011.pdf
identifier: DOI:10.11588/heidok.00017841
identifier: urn:nbn:de:bsz:16-heidok-178410
identifier:   Kamphues, Carsten ; Wittschieber, Daniel ; Klauschen, Frederick ; Kasajima, Atsuko ; Dietel, Manfred ; Schmidt, Sven-Christian ; Glanemann, Matthias ; Bahra, Marcus ; Neuhaus, Peter ; Weichert, Wilko ; Stenzinger, Albrecht  (2012) Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer.  Pathobiology, 79 (1).  pp. 11-17.  ISSN 1015-2008     
relation: https://archiv.ub.uni-heidelberg.de/volltextserver/17841/
rights: info:eu-repo/semantics/openAccess
rights: http://archiv.ub.uni-heidelberg.de/volltextserver/help/license_urhg.html
language: eng