TY  - JOUR
TI  - Prolyl hydroxylase domain 2 protein is a strong prognostic marker in human gastric cancer
SP  - 11
JF  - Pathobiology
AV  - public
ID  - heidok17841
VL  - 79
PB  - S. Karger AG
EP  - 17
IS  - 1
Y1  - 2012///
SN  - 1015-2008
A1  - Kamphues, Carsten
A1  - Wittschieber, Daniel
A1  - Klauschen, Frederick
A1  - Kasajima, Atsuko
A1  - Dietel, Manfred
A1  - Schmidt, Sven-Christian
A1  - Glanemann, Matthias
A1  - Bahra, Marcus
A1  - Neuhaus, Peter
A1  - Weichert, Wilko
A1  - Stenzinger, Albrecht
UR  - https://archiv.ub.uni-heidelberg.de/volltextserver/17841/
N2  - Objective: According to recent research, prolyl hydroxylase domain 2 protein (PHD2) plays an important role in human carcinogenesis by inducing neovascularization and tumor growth. The aim of this study was to evaluate PHD2 expression patterns in primary gastric adenocarcinoma and to test for a potential predictive value of PHD2 expression in gastric cancer patients. Methods: In a total of 121 patients, PHD2 expression was investigated by immunohistochemistry in paraffin- embedded tissue and correlated with clinicopathological parameters and patient survival. Results: 64 of 121 gastric carcinomas (52.9%) showed PHD2 expression in tumor cell cytoplasm. In univariate analysis, PHD2- negative patients had a significantly shortened survival in comparison
ER  -